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Terms in this set (33)
what causes a bleeding disorder?
can result in a defect in on or more steps of the normal clotting cycle... could either be from an inadequate amount of platelets/clotting factors OR a defect in the elements of the cycle
2 causes of Thrombocytopenia
Dimished Production of Platelets can be caused by:
Vit B12/folate/iron deficiency
Increased Destruction of Platelets have 3 causes:
Primary autoimmune= ITP, TTP, HIV
Secondary Autoimmune= systemic lupus, malignancy, drug induced, infection induced
Which platelets disorders lead to internal clotting?
ITP, TTP, HIT, DIC
What else can cause a platelet disorder, other than thrombocytopenia?
Platelets may not be working properly due to...
inherited traits- aggregation. adhesion
acquired traits- increased uric acid, myeloproliferative syndromes
Drug induced traits: NSAIDs, antibiotics, psych drugs
Bleeding Disorders have 2 general characteristics...
2 Inherited Coagulation Disorders include:
Von Willebrand Syndrome
an inherited coagulation factor deficiency!!
FACTOR VIII deficiency
FACTOR IX deficiency
What is Von Willebrand Factor needed for?
necessary for adhesion b/n platelets and the vascular subendothelial wall and b/n adjacent cells
What is the most common inherited bleeding disorder in humans?
Von Willebrand Factor Syndrome
VWFS has 2 categories...
Inherited and Acquired
VWF does not work properly
antibodies to VWF
associated with many diseases and some drugs
no detectable VWF or Factor VIII
What organ synthesizes most of the clotting factors?
Acquired Coagulation Disorders:
Which factor does the liver NOT produce:
leads to decrease in clotting factors; also important for Vit K which is essential for clotting
disseminated intravascular coagulation
pathological activation of coagulation that happens in response to disease; formation of small clots in the body; accelerated clotting results in consumption of platelets and clotting factors leading to hemorrhage
When does DIC occur?
shock, obstetrical complications, trauma, sepsis
What does DIC result in?
MODS- from the mini clots
Hemorrhage- from the consumption of platelets and clotting factors
Patients with Platelet disorders present with....
PETECHIAE and abnormal bleeding time
Patients with Coagulation disorders present with...
ECYMOSSES and deep tissue hemorrhage; abnormal PT and PTT
If a platelet disorder is suspected, but platelets are normal...
suspect a dysfunction
immune thrombocytopenic purpura=
an abnormal autoantibody binds to circulating platelets... if the BM cannot increase production and maintain normal number of platelets= thrombocytopenia and purpura
Thrombotic Thrombocytopenic Purpura=
blood clots form in bvs around the body... use up platelets in the blood and potentially cause damage to organs
Heparin Induced Thrombocytopenia=
abnormal formation of clots... abnormal antibodies activate platelets causing them to begin the clotting cascade
What is DDAVP and what does it do?
indirectly releases VWF and may increase factor VIII in Hemophilia A
Partial Thromboplastin Time
time it takes for blood to clot
PT- also measures clotting time but looks at different factors- usually done at the same time as PTT
THIS SET IS OFTEN IN FOLDERS WITH...
Final GI ( minus HEP)
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