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Chapter 5 Jain-Benign and Malignant Tumors
Terms in this set (32)
Presentation: Light brown to yellow/dar brown papule or plaque with waxy varrucous/stuck on appearence.
Subtypes of SKs
1. Acanthotic SKs: most frequent. Smooth dome shaped with slight hyperkeratosis, but significant acanthosis and invaginated horn pseudocysts.
2. Hyperkeratotic: exophytic lesion with significant hyperkeratosis and papillomatosis
3. Reticulated SK: interacting thin strands of basaloid and pseudocysts
4. Clonal: intraepidermal well defined nest of basaloid cells
5. Irritated SK: squamout eddies within epidermis
6. Pigmented SK: acanthotic, heavily pigmented.
Clear Cell Acanthoma
Benign solitary erythematous papule or plaque often on leg
Pigmented or pink firm, dome shaped papule with central induration
Giant cell tumor of tendon shealth
SLow growing, skin colored nodule on finger or toe. Fixed to tendon sheath
Skin colored or red solitray dome shaped papule most often on nose or central face. Pearly penile papules present as dome shaped small papules on or around corona of glans penus.
Acquired digital fibrokeratoma
SOlitary pink or brown keratotic excrescence on finger with surrounding collarrete of elevated skin.
Solitary or slow growing skin colored to pink papule with soft or rubbery feeling
Tumor of neural tissue
Often sokitary skin colored or erythematous firm papule with associated pain.
1. Traumatic: well circumscribed nodule
PEN: Well demarcated proliferation of palisading spindle cells with encapsulation and fibrotic stroma.
Subcutaneous skin colored papulonodule often on extremity with occasional tenderness and pain
Pink, red, or brown papulonodule often involving head
Erythematous papule, plaque or nodule with characteristic moat surrounding lesion, sharp demarcation between poroid and surrounding keratinocytes
Solitary skin colored nodule with no site predilection
erythematous, blue or gray nodule
Single or multiple firm, rubbery nodules with erythematous to blue color, often on scalp.
Solitary or multiple smooth surfaced or verrucoid papules or nodules on face.
Inverted FOllicular Keratosis
White, tan, or pink papule often on face.
Benign neoplasm with follicular differentation
Presentation: skin colored papule or nodule with predilection for nose, can be singular or multiple
Firm or skin colored erytmatous annular plaque with central depression. Commonly on cheek.
Small papules often clustered over eyelids.
Smooth papule or subcutaneous nodule almost always on vulva
Papule or plaque with papillomatous or crusted surface on head or neck
Granular cell tumor
Often solitary, skin colored to brown red papulonodule often on head/neck
reddish brown, pink or skin colored papules. Usually seen in adolescence or early childhood
Reed syndrome. This and uterine leiomyomas. Increase risk for renal malignancies
TUmor of mature lipocytes and blood cells
Subcutaneous nodules often on forearms of young adult usually with pain.
Premalignatn lesion in sun exposed areas.
Presents as erythematous macules or thin papule with adhreent scale
SCC in situ presenting as well demarcated erythematous patch or plaque, predilection for legs in women and scalp in men
secomd most common skin cancer.
Presents as erythematous keratotic papule, plaque or nodule in sun esposed areas.
Increase risk in organt transplant patients.
Subtype of SCC
Presents as rapidly enlarging papule or nodule often appearing crateriform with keratolitic center.
1. KA centrifugum marginatum- may reach several centimeters in diameter, concomittant expansion of border and central healing.
2. Giant KA: Rapid enlargement to several centimeters
3. Ferguson smith: sudden onset of multiple KAs in childhood
4. Grzybowski type: suddeon onset multiple AKs in adulthood.
Basal cell carcinoma
Superficial BCC-pink think plaque with pearly border
Nodular BCC: Most common: translucent papule or nodule with overlying telengectasias
Morpheaform BCC: Indurated firm plaque with ill defined borders resembling a scar. Aggressive growth pattern
Metatypical BCC: features of both BCC and SCC
More types that I will add later
Merkel cell carcinoma
rare, but highly aggressive neuroendocrine tumor
Presentation: red to pink dome shaped rapidly growing nodule involving head and neck
Treatment: wide excision
Aggressive tumor resulting from melanocytes and affecting younger population
1. Superficial spreading- Mos tcommon: presents as darkly pigmented macule or thin plaque
2. Nodular melanoma: Darkly pigmented papule or nodule with rapid onset
3. Lentigo Maligna melanoma: least common. Evolves from lentigo
4. Acral leniginous melanoma: common in darker patients. Hyperpigmented patch with varrying shades of brown or black and irregular borders.
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