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Pharm Quizzes and Review Questions
Terms in this set (73)
The cellular assembly which recognizes/interacts with one or more chemical mediators/drugs and initiates a chain of events leading to a drug's effect-
What is the largest receptor family and Are the target for approximately 40-50% of all drugs
What is affected by extent of absorption, first pass elimination, and rate of absorption?
Drug bind to receptor +activate receptor to produce effector/resp
Competitive Antagonist vs. Irreversible Antagonist
Comp. Antagonist-antagonist binds to same site as agonist to compete for same site Irreversible- Non-comp. antagonist binds -->diff site than agonist- does not compete
you can elicit maximal response at an agonist concentration that doesn't occupy all the available receptors;
Which drug is considered Considered low efficacy drugs?
Kd - dissociation constant-
concentration of drug needed to bind 50% of receptors
What is listed on the DO NOT USE sig list?
What is extraction rate dependent on?
flow rate to the organ
Target concentration (TC)
that which produces the desired therapeutic effect/objective without exceeding the minimum toxic concentration
2 most important variables in renal function
CLcr(creatinine clearance) and GFR (glomerular filtration rate
When is it safe to administer Tigecycline to children
What is described as an extended spectrum Penicillin and a combination consisting of a PCN with a beta-lactamase inhibitor with clavulanic acid?
Mechanism of action of beta- lactam antibiotics penicillin and cephalosporins
To inhibit bacterial cell wall synthesis
Clavulanic acid, calbactam, tazobactam are always given in combination with antibiotics that have what of the same actions in common?
Which of the following would be okay to take at the same time as fluoroquinolones such as levofloxacin?
You have a patient who has HIV and needs prophylactic tx for pneumocystis he is otherwise healthy and has a PCN allergy which of the following drugs would be a good choice?
Bactrim, trimethoprim, sulfisoxazole
Which of the following drugs works by inhibiting bacterial hydropholic acid reductase?
Which of the following antibiotics is highly active against chlamydia and gonorrhea?
Which of the following drugs must be administered with cilastatin or is inactivated in the renal tubules?
Which of the following drugs is a third generation cephalosporin that is cleared via the biliary tract?
Cefoperazone & ceftriaxone
Which of the following are the correct are the four drugs used for the first line of TB?
Isoniazid, Rifampin, Ethambutol, & Pyrazinamide
Which of the following drugs is a decenticanded indicated for disseminated mucocutaneous candida infection
Which of the following antifungal is available as an oral liquid only?
Which of the following is a cumulative side effect of Amphotericin B
Renal and liver function Abnormalities
Which of the following is the drug of choice for some hookworm, roundworm infections and is used as an alternative pinworm infection and is available over the counter?
Which of the following is the drug of choice treatment of onchocerciasis or river blindness, cutaneous larva migrans, strongyloidiasis and some forms of filariasis?
Sodium stibogluconate is the primary drug in the treatment of all forms of leishmaniasis, what is believed to be the mechanism of action for this drug?
Kill parasites by inhibition of glycolysis or effects on nucleic acid metabolism
Which of the following is the drug of choice prophylaxis and treatment for pneumocystis pneumonia?
Which of the following amebiasis drugs has adverse effects on the thyroid gland?
Iodoquinol (iodine affects your thyroid gland)
Amebiasis treatment is based on the severity of infection, which of the following drugs should be used for an asymptomatic infection
What is the brand name of the antimalarial drug chloroquine?
What is the adult chemoprophylaxis in chloroquine areas without resistance to p. Falciparum
500 mg once a week
What is the requirement for several of the antifolate and antimalarial drugs due do a common adverse effect?
Which of the following drugs can be used to treat Staph aureus colonization in the nasal pathways?
Which of the following antiviral agents is used to treat HSV and varicella zoster and is available as oral and IV?
What term is described as a chemical or physical tx that destroys most vegetative microbes or viruses in or on an inanimate surface, but does not work against spores?
Which of the following drugs can be used to help treat symptoms of a UTI but does not actually treat the infection itself?
Which of the following drugs is indication to use to treat an uncomplicated UTI?
You have decided to prescribe metronidazole to your patient John, he takes a lot of over the counter medications, which of the following should he avoid due to the disulfide reaction that can occur?
Which of the following drugs is reduced to ferredoxin and creates toxic by products to exert its bactericidal actions?
HIV medications can cause many side effects, which HIV med can precipitate psychiatric symptoms?
Which of the following drugs is considered first line treatment in a pregnant HIV positive patient?
What is the prefered oral treatment for CMV?
You have a patient traveling to a known chloroquine resistant area, which of the following drugs does the CDC recommend as a single agent of chemoprophylaxis for all malaria areas, except areas that are not chloroquine resistance?
Sulfonamides are usually combined with an antifolate drugs, which two are antifolate drugs?
Trimethoprim and pyrimethamine (toxoplasmosis)
Fluoroquinolones can be used to treat all of the following except?
What is a dangerous side effect that fluoroquinolones can cause?
Bactrim can used to treat all of the following except?
What drug should be given to treat crystalluria caused by high dose sulfide?
Do macrolides require renal adjustment?
It is okay to administer tums with levaquin?
What are the direction on a Z-pack?
Take 2 doses of one tablet for 4 days
Which of the following drugs can cause auditory damage?
Emicacin (same class as streptomycin and gentamicin)
What is the correct strength of treatment for bactrim DS?
Renal adjustments are required for all floroquines except?
Which of the following floroquinoes has the most active against p aeruginosa?
Which generation of cephalosporins is contraindicated for a patient that has an anaphylactic reaction to penicillin
Metronidazole can cause a disulfide reaction if what?
What is Steven Johnson syndrome?
Severe rash- blister and peeling skin around mucous membranes
What is the drug of choice for thrush?
Which of the following drugs can be used for staph of the nares?
What is the first line treatment for acute toxoplasmosis?
Pyrimethamine and Sulfonamides
Can you give tetracycline during pregnancy?
At what age can you give tetracyclines to children?
8 and above
Which of the following antibiotics has a adverse reaction of red man's syndrome?
Which of the following is used as a first line treatment for HIV in pregnant women?
What is the treatment used in patients with chlamydial conjunctivitis?
What is clavulanic acid added
Protects amoxicillin from lactamases
How common is a true anaphylactic reaction to penicillin?
What toxicity is caused with aminoglycosides, especially with high trough levels?
Which of the following is not a topical antifungal
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