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Biochemistry Nucleic Acids Chp7
Terms in this set (11)
Phosphoric Acid is an _______ acid with 3 protons available to be donated. These protons have high Ka's, thus in bodily environments they are often found ____________.
2 orthophosphates (orthophosphates same as phosphates) bound together by ________ linkage form a ____________.
anhydride linkage ; pyrophosphate
Pyrophosphate can be likened to _____ _______
How is it possible the delta G for ATP hydrolysis is higher in physio conditions than standard conditions?
There is a lot more ATP available thus an increase in Q, which will increase delta G
The 5' end of a nucleic acid is the beginning of the sequence and contains the ______ _____
3' end of the nucleic acid is the end of the sequence and contains the _____ _____ group
free hydroxyl group
If you attached methyl groups to all the acidic phosphate oxygens along the length of a DNA double helix, would the chain have a higher or lower Tm than normal DNA?
The methyl groups act as caps for the charged oxygens, thus they are no longer repelled by one another, this increases Tm since now you need more energy to break the nucleotides apart
The oligonucleotide ATGTAT is complementary to ATACAT
The ratio of purines to pyrimidines is
Based on your knowledge of the interactions of macromolecules and that DNA is negatively charges, do you suppose that histones are mostly basic or acidic?
Histones are composed of proteins, most likely positively charged proteins which are attracted to the negative DNA strands.
Positively charged proteins are the basic proteins
Describe the structure of DNA from Deoxyribose to chromatin
Deoxyribose--(add a base)-->Nucleoside--(add 3 Pi)--> Nucleotide--(Polymerize)-->Oligonucleotide--(Continue polymerization)--> Polynucleotide--(H-bond two complementary Polynucleotides)-->dsDNA--(coil them)--> dsDNA helix--(wrap around histone)--> Nucleosome--(Complete packaging)--> Chromatin
Anticancer drugs often seek to block the growth of rapidly dividing cells by inhibiting the production of thymine. Why is this an attractive target for cancer therapy
RNA is needed in everyday maintenance of cells, DNA is not. A difference between the two is uracil vs thymine, thus targeting thymine production limits DNA replications which then limits Cell replication.
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