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Parkinson Disease
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Parkinson Disease
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A progressive neurological disorder that primarily affects movement.
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marleneagosto
Terms in this set (66)
Parkinson Disease
A progressive neurological disorder that primarily affects movement.
initially unilateral hand tremors, but progresses to bilateral tremors, rigidity, bradykinesia, and postural instability
What are some characteristics of PD?
Dopamine
What is the brain transmitter that regulates voluntary movement, reward-seeking behavior, memory and learning, attention, and affect?
Motor
What type of deficit results from the progressive loss of dopaminergic neurons in the substantia nigra and other areas of the brain?
When 60-80% of the dopamine is lost.
When do motor deficits begin?
oxidative stress, impaired mitochondrial function, and protein misfolding and aggregation.
Dopaminergic cell death is a result of...
Lewy bodies in neurons; are abnormal aggregates of proteins, including alpha-synuclein.
PD is characterized by the presence of __________. Which are...
dopamine and acetylcholine
What two things need to be balanced to produce smooth movement?
is increased, causing imbalance that contributes to the clinical manifestations of Parkinson disease.
When dopamine neurons are degenerated, acetylcholine...
Unknown, but its believe the combo of genetic susceptibility and exposure to environmental factors or toxins.
What's the cause of PD?
