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Terms in this set (24)
Inflammation is the most important mechanism in which kind of immunity?
Create a Barrier, Clear Pathogens, Remove Damaged Tissue, Promote Healing
What does the focused response of inflammation do? (4)
Redness, Swelling, Heat, Pain, Loss of Function
What are the 5 cardinal signs of inflammation?
Pus formation can occur if lots of what are present?
Acute Inflammation (hours to days)
Type of inflammation characterized by exudation of fluid & plasma proteins, as well as a neutrophilic infiltration
Chronic Inflammation (days to years)
Type of inflammation characterized by mononuclear infiltration (mainly macrophages), fibrosis, granuloma formation, multinucleated giant cells, vascular proliferation, & scarring
Histamine, Proteins, Lipids
What are the major types of soluble inflammatory mediators released by the site of inflammation by sentinel cells? (3)
Soluble inflammatory mediator released by sentinel cells that causes vasodilation & increased vascular permeability
Complement Proteins, Cytokines
What are the major types of proteins released by sentinel cells at the site of inflammation? (2)
IL-1, IL-6, TNF-alpha
What are the major cytokines that help with recruitment and activation of leukocytes? (3)
What type of lipids are responsible for pain?
Vascular Changes, Leukocyte Recruitment, Systemic Effects
What are the major types of effects that occur during Inflammation? (3)
Gram Negative (LPS)
What type of bacteria commonly release exogenous pyrogens in blood that can cause a fever?
During a fever, what do endogenous pyrogens induce the synthesis of that cause the hypothalamus to raise its set point?
NSAIDs (aspirin, tylenol, motrin)
What are Prostaglandins inhibited by?
Iron, Copper, Zinc
What serum levels are needed for bacterial reproduction that can be decreased by a fever? (3)
What beneficial effect does a fever have on leukocytes?
Macrophages, Dendritic Cells
When stimulated via innate immune response, what makes pro-inflammatory cytokines? (2)
Cytokines that signal to endothelial cells that blood vessels are leaky to fluid, causing influx to site needed of plasma containing antibodies, complement proteins, etc. (2)
Cytokine that promotes adaptive immune responses & has systemic effects
C-Reactive Protein (CRP)
Protein produced by liver that rises during inflammation & is used clinically as an indicator of systemic infection
NSAIDs, Glucocorticoids, TNF Blocker, IL-1 Blocker
What are 4 major examples of anti-inflammatory therapeutics?
Potent anti-inflammatory drug with natural systemic anti-inflammatory mechanism
Rheumatoid Arthritis, Crohn's Disease
What are agents that block TNF used to treat? (2)
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