Roach Clinical Pharmacology Ch 1
Roach Clinical Pharm 1
Terms in this set (41)
the study of drugs and their action in living organisms
type of complementary/alternative therapy that uses plants or herbs to treat various disorders; aka. Herbalism
The scientific term that describes the molecular structure of a drug
Considered the official name of a drug; marketed by any company and given to the drug by the U.S. Food and Drug Administration (FDA)
Brand name; registered by the manufacturer and is followed by the trademark symbol
Drug the federal government had designated as potentially harmful unless their use is supervised by a licensed health care provider, such as a nurse Practitioner, physician or dentist
Undesirable drug effect
Poisonous or harmful
Drugs that are designated by thee FDA as safe
Drugs that have the potential for abuse and dependency, both physical and psychological
Orphan Drug Act of 1983
An act that was passed to encourage the development and marketing of products used to treat rare diseases
Pertains to the phase during which a drug dissolves in the body
Drugs given by injection
Transportation activity of drugs in body after administration
drug is moved form site of administration to body fluids; first process during pharmacokinetics
Study of the drug mechanisms that produce biochemical or physiologic changes in the body
Action by which an oral drug is absorbed and carried directly to the liver, where it is inactivated by enzymes before it enters the general bloodstream
Time required for the body to eliminated 50% of a drug
Elimination of a drug form the body
Drug is changed to a form that can be excreted
Drug moves form circulation to body tissue or a target site
A reactive site on the surface of a cell; when a drug binds to and interacts with the receptor, a pharmacologic response occurs
Is any substance that causes abnormal development of the fetus often leading to severe deformation
Extremely serious allergic drug reaction that usually occurs shortly after the administration of a drug to which the individual is sensitive
Synergistic Drug Reaction
Produce an effect that is greater than the sum of their separate action
Antagonistic Drug Reaction
Drug reaction occurs when one drug interferes with the action of another, causing neutralization or a decease in the effect of one of the drugs
20-100 Individuals who are healthy volunteers
People who have the disease or condition for which the drug is thought to be effective
Drug is given to large numbers of patient in medical research centers (hospital) to provide information about the adverse reactions
Post marketing surveillance (occurs after the manufacturer places the drug on the market)
When health care providers report Sid effects of the drugs?
Where do capsule drugs disintegrate into small particles and dissolve into the body fluids?
For drugs that have enteric coating or time-release capsules they do not disintegrate until they reach the alkaline environment of the?
Absorption, distribution, metabolism, and excretion
What are the pharmacokinetic phases in order?
Action by which an oral drug is absorbed and varied directly to the liver, where it is inactivated by enzymes before it enters the general bloodstream
2 to 4 hours
How long does short-half life last?
How long does long half-life last?
Time between administration of the drug and onset of its therapeutic effect
Absorption rate equals the elimination rate
Time the drug produces a therapeutic effect
Alteration in cellular function or cellular environment
A drug exerts its action by one to two main mechanisms?
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