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24 terms

Pharmacology

Test 2
STUDY
PLAY
Define Pharmacology
The study of drugs, their actions on living organisms, and how they affect the body cells
What is the most important goal of pharmacology?
The safe and accurate administration of meds
What 4 things do we need to know about the Pt?
Current HHx
-present circumstances
-pain
-nausea
-Sleep
-Religious patterns

Present HHx
Past HHx
Drug Hx
Define Pharmacotherapeutics
Use of drugs to treat, cure, relieve, or prevent disease
Define Pharmacodynamics
Process by which drug changes body
Pharmacokinetics
study of time req. for absorption durtaion and action&effect, distribution in body and method of excretion
4 Drug Names
Chemical Name- chemical make up
Generic Name-before drug is approved
Offical name-given by USP often same as Gen.
Brand name-Trade name given by manufact..
Examples of the 4 Drug names
Chemical-aetylsalicylic acid
Generic-Aspirin
Official-Aspirin
Brand- Bufferin, Excedrin, Bayer, St. Josephs
Drugs are classified how?
By:
Characteristics
Symptoms relieved
Desired Effects
Aspirin is classified how-
Analgesic
Antipyretic
NSAID
Anticoagulant
Absorption (p 839)
...
Route of Administration
Doctors orders
Nurse cant change independently
Acidity or Alkalinity
Acid- stomach absorbs well
Base- better absorbed in intestines
Distribution can be affected by:
Circulation
Membrane permeability
H20 and fat
Protein binding
Membrane permeability
blood brain barrier
-fat soluble meds get through but H20 doesnt
-antibiotics have difficulty

Placental barrier
-not very selective about what crosses
Define Teratogenic
agent or factor that causes malformation of embryo
OA variations of H20 and fat:
lower water= doesn't distribute as well
higher fat= longer duration of drug action
slower drug distribution
lower weight means higher Cnx
Protein binding:
Agonist- same response as physiologic/ endogenous substance

Antagonist- inhibits cell function by occupying receptor sites
Albumin
binds to many drugs making them ineffective
Descrie biotransformation
when meds change into less active or inactive form, as related to the metabolism
Main organs of Excretion:
1* = Kidneys
2*= bowel, lungs,
exocrine glands- breast sweat
Give 2 examples of pharmacodynamics
Insulin, or synthetic thyroid hormone
Effects to Drugs
Therapeutic Rxn
Side Effects
Adverse Effects
Toxic effects
Idosyncratic rxn
Allergic rxn
Mild Allergic reaction
Uticaria- raised irregularly shaped lesion

Rash- small raised vesicles

Pruritus- itching of skin

Rhinitis-inflammation of mucus membrane of nose

Lacrimal Tearing- excessive tearing