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lecture 3- intro to dosage forms

Terms in this set (43)

What are differ sources of drug?
-plant
-animal
-mineral
-semi-synthetic
-synthetic
(a drug is rarely administered in original form)
What does API stand for?
Active Pharmaceutical Ingredient
Why are dosage forms important?
-because API handling & dosing can be difficult
-enhances the stability of API in the external environment
-protects the API degradation @ the site of administration
-help w/ unpleasant tastes/odor
what are the desirable properties of dosage form?
-convenient to handle, use, and store
-stable
-not disrupt the pharmacological activity of drug
-differ strengths
-protect the drug substance
-cheap
What are the physical states of dosage forms?
-solid
-liquid
-semisolid
-gaseous
what are examples of solid dosage forms?
-powders
-tablets
-capsules
-granules
-pills
-lozenges
-troches
what are examples of liquid dosage forms?
-solutions
-suspension
-emulsion
what are examples of semisolid dosage forms?
-ointment
-pastes
-creams
what is an example of gaseous dosage form?
-aerosols
advantages of solid dosage form?
-easy to carry & transport
-stable
-easy to administer
-available in differ strengths
disadvantages of solid dosage forms?
-difficulty to swallow
-delay in the onset of action
-gastric irritation
Advantages of liquid dosage forms
-effective more quickly than solids
-easier to swallow
-reconstituted lyophilized powders (easy to place in feeding tube or injection)
-flexible in dosing
disadvantages of liquid dosage forms?
-bulky (high cost of transportation)
-stability is an issue
-need an accurate device to measure
-unpleasant tastes & odors
advantages of semisolid dosage forms?
-easy to apply on skin
-could be used for both topical and systemic delivery
-emollient (smoothing) action can be achieved
-can be compounded extemporaneously (w/o preparation)
disadvantages of semisolid dosage forms?
-pastes are not suitable for application to hairy areas
-occlusive (prevents the flow of air)
-difficult to remove
-incorporation of certain drugs is a bit challenging
-stability: phase separation
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