# NURS 314 Infection and Immunity

Infection
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Terms in this set (73)
the collection of all the microorganisms living in association with the human body. These communities consist of a variety of microorganisms including eukaryotes, archaea, bacteria and viruses. Bacteria in an average human body number ten times more than human cells, for a total of about 1000 more genes than are present in the human genome. Because of their small size, however, microorganisms make up only about 1 to 3 percent of our body mass (that's 2 to 6 pounds of bacteria in a 200-pound adult). These microbes are generally not harmful to us, in fact they are essential for maintaining health. For example, they produce some vitamins that we do not have the genes to make, break down our food to extract nutrients we need to survive, teach our immune systems how to recognize dangerous invaders and even produce helpful anti-inflammatory compounds that fight off other disease-causing microbes. An ever-growing number of studies have demonstrated that changes in the composition of our microbiomes correlate with numerous disease states, raising the possibility that manipulation of these communities could be used to treat disease
The immune response: collective and coordinated response of cells of the immune system

Protects host from foreign invaders such as pathogens, bacteria, parasites, viruses

Distinguishes self from non-self (Cancer, autoimmune reactions, transplants)

Mediates healing (i.e. Inflammatory response, wound repair)

Dysfunction ➔ autoimmunity, immunodeficiency, allergies, hypersensitivity, transplant pathology

Mostly protective but can produce undesirable effects such as when response is excessive (allergies) or when it recognizes self tissue as foreign (autoimmune disease)