Cell Bio Exam 2

HIV
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Terms in this set (14)
HIV
Human Immunodeficiency Virus
AIDS
Acquired Immune Deficiency Syndrome
First step in HIV replication path way
Attachment
Second step in HIV replication path way
Reverse Transcription
Third step in HIV replication path way
Integration/Transcription
Fourth step in HIV replication path way
Translation
Fifth step in HIV replication path way
Viral Protease
Sixth step in HIV replication path way
Assembly & Budding
Which steps in HIV replication pathway cannot be used as drug targets?
1) Reverse Transcription
2) Translation
2 reasons the traditional vaccine-development strategy does not work for anti-HIV vaccines
1) HIV has a high mutation rate
2) It cannot be grown in a lab, deactivated and then injected
Rational Strategy for anti-HIV vaccine development1) Determine which proteins of the HIV virus are antigenic 2) Find conserved regions or find conserved epitope in this antigenic protein 3) Copies are made of the conserved sequence and use that as a vaccineA peptiodoglycan is a polysaccharideA polymer that has sugars and amino acids forming a layer that protects the bacterial cell wallHow do amino-acid interactions with the substrate make peptiodoglycan vulnerable to breakdownThe substrate binds to the active site and water comes in and binds to the molecule which causes it to break