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SI Practice Test 3 Immuno

Terms in this set (50)

One TCR can bind to different antigens
false
MHC genes are diverse because
they are polymorphic within the population
which of the following statements is TRUE regarding TCRs?
Has 2 chains, each with a constant and a variable region
The alpha locus:
-will contain the Cdelta gene
-Has V and J gene segments
which statement is/are TRUE regarding SCID?
T cells are not functional because with SCID, TCR recombination is affected
Once a T cell has rearranged a TCR, which of the following membrane proteins will it need to leave the ER to get to its final destination?
Two epsilon, one gamma, one delta, 2 zeta
the importance of the zeta chain is in
the role they have in transduce the signal from the extracellular space to the intracellular space
A gamma:delta Cell is restricted to recognition of antigens through MHC molecules
false
A MHC I:
-one transmembrane chain, three alpha chains, and one Beta2 microglobulin
-has one alpha1 and one alpha 2 that will form the peptide binding site
a CD4 TH1 cell, that was previously activated by a dendritic cell (who presented exogenous peptides through an MHC I), will activate macrophages so that they can start secreting cytokines and phagocytize the pathogen thats infecting
false
theMembrane Attack Complex (MAC) is formed by:
C3b2Bb and C4b2a3b
the Beta2 microglobulin gene is encoded in the same loci as the MHC genes
false
little jimmy was taken to the doctor because of an upper respiratory infection that he does not seem to be able to clear (has a chronic respiratory infection. A differential blood cell count showed that jimmy had a normal lymphocyte count, but a genetic mapping of his HLA genes showed that there were several mutations that affected his TAP proteins. Most likely jimmy has:
-no opportunity to load peptides on an MHC I molecule
-Bare Lymphocyte Syndrome
A gamma:delta T cell:
is not restricted to antigen recombination by MHC presentation
The max number of MHC I genes Prof Weigel could receive from his parents, in the event that he is homozygous for the MHC I locus is:
3
which of the following statements regarding CD4 T cells is/are NOT true?
-can differentiate into only 2 subcategories: TH2 and TH1
-CD4 TH1 cells will stimulate B cells to produce antibodies
-Are cytotoxic cells that specialize in killing cells who are infected with intracellular pathogens
A mutation in the MHC locus will affect the Beta2 microglobulin gene
false
Which of the following statements is/are true?
MHC I can present antigen to CD8 T cells, and MHC II can present antigen to CD4 T cells
the immunoproteasome:
is the enzyme that is only activated when a cell is infected with a virus, whereas the constitutive proteasome is the enzyme that normally degrades proteins
which statement about Calnexin is/are true?
-will release the MHC I when the beta2 microglobulin binds to teh alpha 1 chain
-is a chaperone protein
The TAP heterodimer will transport:
polypeptides of more than 8 amino acids
BEFORE the MHC II enters the phagolysosome:
the MHC II will be in an endocytic vesicle called MIIC, where proteases will cleave the invariant chain that are blocking the binding site of the MHC II, leaving just the CLIP
can a macrophage load an extracellular peptide on an MHC I?
yes, a macrophage can load an exogeneous peptide both on MHC II and MHC I
when interacting with a TCR, the peptide loaded on the MHC will mainly interact with the ___ region of the TCR, while the ___ and ___ regions will interact and recognize the MHC
CDR3; CDR1; CDR2
HLA-A:
-will present antigen to a CD8 T cell
-is one MHC I isotype. Other isotypes include HLA-B and HLA-C
a bone marrow transplant can
lead to a graft vs. host response
which of the following is/are a secondary lymphoid tissue?
-peyers patches
-spleen
arrange the development stages of the B cell in the correct order:
early pro-->late pro-->large pre-->small pre-->immature-->mature
A large pre B-cell is distinguished by:
-pre B cell receptor which consists of a heavy and a surrogate light chain with its Igalpha and Igbeta side chains
-has a surrogate light chain that tests whether the H chain will be able to bind to the L chain
a large pre b cell who just assembled a pre b cell receptor will:
include allelic exclusion by signaling the cell to turn off RAG genes and destroy RAG2
a large pre b cell will rearrange its V/J segments of the L chain at the same time that the VDJ gene segments of the H chain are being rearranged
false
The surrogate light chain:
is composed by 2 structures, VpreB and gamma5, that test the binding of the H chain to the L chain
you can find small pre-B cells in your body with surrogate light chains
false
mature B cell will choose whether to produce IgM or IgD thorugh:
mRNA splicing
a mature b cell will choose whether to produce a soluble Ig or a BCR through:
mRNA splicing
stromal cells:
produce IL-7 which will stimulate the growth and proliferation of pre-B cell
If the first H chain rearrangement attempt of a B cell is unproductive:
its going to use its homologous chromosome to try a second rearrangement
less than half of the total number of b cells produced in the bone marrow are able to produce a functional antibody
true
The first L chain rearrangement attempt of a B cell is unproductive:
I will be able to try to rearrange the K gene on the homologous (second) chromosome. If this second rearrangement is also unproductive, the B cell will be able to attempt rearranging the gamma genes on the first chromosome. If the third attempt yields and unproductive rearrangement, the B cell will be able to attempt a final rearrangement of the gamma gene on the second chromosome. If all these fail to yield a productive light chain, the B cell will die by apoptosis
Pre-BCR is also known as the ___ checkpoint, which is a ___ signal that ___ apoptosis.
1st, positive, prevents
RAG1 and RAG2 are:
turned on and off twice; the last time these are turned off is when the B cell is able to produce a BCR with Igalpha and Igbeta
A translocation of the MHC gene will:
cause Burkitt's lymphoma
Which of the following statements/regarding B1 cell is/are true?
They are known as CD5 cells
Prenatal B1 cells have little diversity because
TdT is not expressed in the prenatal period
if an immature B cell that is reactive to multivalent self-antigen is not eliminated:
there is a risk of developing an autoimmune disease
receptor editing refers to:
B cell utilizing TdT enzymes to produce a new L chain productive rearrangement after recognizing a multivalent self-antigen
B cells enter the secondary lymphoid tissue through:
high endothelial venules
Chemokines __ and __ attract B cells to the HEV and lymph node respectively.
CCL21; CCL19
In the germinal center:
-centroblasts are large proliferating B cells
-centrocytes and FDC occupy the light zone
Plasma cells can differentiate directly from:
-activated B cells
-isotype switched B cells
-hypermutated centrocytes
-memory B cells
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