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8 terms

Medications and GI System

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Dicyclomine HCl (Bentyl)
Suppresses peristalsis and decreases gastric emptying
Opioid analgesics
Slow peristalsis and segmental contractions, often resulting in constipation
Anticholinergic drugs such as atropine or glycopyrrolate (Robinul)
Inhibit gastric acid secretion and depress gastrointestinal (GI) motility (Lehne, 2010) (Although useful in treating hyperactive bowel disorders, anticholinergics cause constipation.)
Antibiotics
Produce diarrhea by disrupting the normal bacterial flora in the GI tract (An increase in the use of fluoroquinolones in recent years has provided a selective advantage for the epidemic of Clostridium difficile)
Nonsteroidal antiinflammatory drugs
Cause GI irritation that increases the incidence of bleeding with serious consequences to older adults; rectal bleeding is often observed with GI irritation
Aspirin
Prostaglandin inhibitor; interferes with the formation and production of protective mucus and causes GI bleeding
Histamine2 (H2) antagonists
Suppress the secretion of hydrochloric acid and interfere with the digestion of some foods
Iron
Causes discoloration of the stool (black), nausea, vomiting, constipation (diarrhea is less commonly reported), and abdominal cramps