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*Stimulates kidneys to reabsorb sodium
-Water follows the sodium osmotically
-Increases both blood volume and blood pressure
*Stimulates kidneys to secrete potassium
*Stimulates kidneys to secrete hydrogen
Aldosterone: Stimulation of Release
*Adrenocorticotropic Hormone (ACTH)
-Minor role in aldosterone release
-Secreted by anterior pituitary
*Renin causes aldosterone to be produced
*Renin released in response to:
-Low blood sodium (hyponatremia)
-High blood potassium (hyperkalemia)
-Decreased blood volume/blood pressure
Aldosterone: Inhibition of Release
*Inhibition of aldosterone is manifested by inhibition of renin
-High blood sodium (hypernatremia)
-Increased blood volume/blood pressure
-Characterized by high aldosterone and low renin
-Renin levels are low due to negative feedback
-Caused by adrenal cortex tumor
-Characterized by high aldosterone and high renin
-Caused by high renin production in the kidney
Aldosterone: Where Produced
*Zona Glomerulosa—outer layer of the Adrenal Cortex of the Adrenal Gland
*Cause of Primary Aldosterone
*Caused by an adrenal cortex tumor
*Characterized by high aldosterone and low renin levels
*Renin levels are low due to negative feedback
-Adrenal cortex producing high levels of aldosterone has an inhibitory effect on the kidney's production of renin
Aldosterone: Hypersecretion Symptoms
*Hypernatremia (high sodium)
*Hypokalemia (low potassium)
*Alkalosis (high pH)
Aldosterone: Hyposecretion Symptoms
*Hyponatremia (low sodium)
*Hyperkalemia (high potassium)
*Acidosis (low pH)
*Hypotension (low blood pressure)
*Cause of hyposecretion of aldosterone
*Autoimmune destruction of the adrenal cortex
*Also causes hyposecretion of cortisol (which is also made in the adrenal cortex)
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