-Anemia: normocytic, normochromic
-RBCs form rouleaux due to ^'d viscosity from abnormal proteins
-WBC & platelets counts usually normal
* often markedly elevated, > 100 mm/hr
Note: What other diseases have a markedly high ESR?
-Polymyalgia rheumatica, Temporal Arteritis, other cancers with hyperfibrinogenemia.
-55% produce IgG
-20% produce IgA.
-Total protein, BUN, creatinine, uric acid elevated
-Hypercalcemia in 1/3 of patients
-40% Bence Jones proteinuria
* need sulfosalicylic acid urine test to detect.
-Serum protein electrophoresis SPELP:
* increased monoclonal Ig protein, or "M protein" in 80%