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antiparasitics: 1) AE 2) drug-drug 3) contraindications

Terms in this set (15)

1) prolonged use: tinnitus, retinopathy, pruritis, abd pain
2) avoid antacids 4hrs before/after
3) pts w/ retinal/visual field changes
Chloroquine
1) high dose: MI & neuro dysfxn
2)
3) pts w/ major psych disorders, DIVERS, PILOTS, pregnancy cat. B 2nd & 3rd trimester only
mefloquine
1) cinchonism, tinnitus, headaches, dizziness, flushing, DEAFNESS
2)
3) pregnancy cat. X, esp. 1st trimester
quinine
1) dark urine=hemolysis, must be stopped, GI distress, leukopenia
2) other blood schizonticides, take w/ food
3) avoid during pregnancy, G6PD deficiency=hemolytic anemia, parenteral rt.= hypotension
primaquine
1)
2)
3) pregnancy cat. C
atovaquone
1) flu-like symptoms, diarrhea, abd pain, headache
2) combined w/ CQ to target CQ-resistant malaria
3) pregnancy cat. C
proguanil
1) high dose= neurotoxicity effects, discontinue if diarrhea, iodine toxicity, nausea, abd cramps
2)
3)
iodoquinol
1) unpleasant taste, dark urine, psychosis, disulfiram-like rxns that disrupt normal alcohol metabolism
2) no alcohol w/in 12 hrs before, avoid for 24 hrs after
3) use w/ caution in 1st trimester for Trich.
metronidazole
1)
2)
3) Pregnancy cat. C
paramomycin
1) headache, dizziness, GI distress, neurological sympt.
2)
3) ocularcercosis= irreversible lesions, do not take w/ CYP inducers like Rifampin, cat. B
praziquantel
1) alopecia, recent hepatotoxicity cases
2)
3)
albendazole
1) least amount of AEs, alopecia, GI distress
2)
3) NOT for pregnancy
mebendazole
1) minor GI disturbance, headache, weakness
2)
3) NOT for hepatic dysfxn, absorbed drug is eliminated via bile
pyrantel pamoate
1) Mazzoti rxn (shock-like w/ fever & resp. distress, dizziness, nausea, fever, headache
2)
3) renal impairment (excreted through urine)
diethylcarbamezine
1) fatal neurotoxicity, Mazzoti rxn (shock-like, w/ fever & resp. distress)
2)
3) NOT for pregnancy
ivermectin
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