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Testicular Tumors (22p)
Terms in this set (76)
Mc tumor in males between 15 & 34 y/o?
------- is the most significant risk for testicular cancer, increasing the risk up to 11-fold
Who has increased risk for testicular cancer: caucasians or AA?
Testicular cancer is associated with accurate serum markers such as ---- and ---
B-hCG and AFP
MC histologic type of testicular cancer in men older than 60?
What is TDS?
Testicular dysgenesis syndrome (failure of development of testes)
3 possible etiologies for testis cancer?
2. scrotal trauma
1. sperm = -----
2. testicular volume less than -----
1. Poor (azospermic)
Association of mumps and testicular cancer? (aka the %)
What foods (2) have been linked to testicular cancer?
milk & cheese (dairy has +estrogen/progesterone)
What is the testicular cancer susceptibility gene?
What is the MC symptom for testicular tumor?
painless nodule/swelling of one gonad
Name 2 possible systemic endocrine effects of a testicular tumor?
Yolk sac tumors are associated with high AFP or B-hCG?
Which have normal serum tumor markers?
(Choose yolk sac tumor; choriocarcinoma; seminoma?)
horiocarcinomas are associated with elevated AFP or B-hCG?
Male Germ cell tumors are divided into ----- &-------
seminomatous & non-seminomatous
Seminomatous or nonseminomatous germ cell tumors are composed of cells that resemble primordial germ cells?
Name 5 GCT's
seminoma; embryonal carcinoma; yolk sac tumor; teratoma and choriocarcinoma
Of the 5 GCT's which 2 manifest usually in the first 4 years of life and always before puberty? (choose seminoma, embryonal carcnoma, yolk sac tumor; teratoma and choriocarcinoma)
Yolk sac & teratoma (earliest)
Infantile, Adolescent or spermatocytic seminomas are not influenced by the initiation and maintenance of spermatogenesis?
infantile (kind of common sense, but I'd miss something stupid like this) - organoid replication
spermatocytic seminomas only occur in what pt population? (hint- think in terms of age)
Intratubular testicular germ cell neoplasia (ITGCN) is also known as -----
Carcinoma in situ
Infantile-prepubertal is/is not preceded by ITGCN?
Spermtocytic seminomas are/are not preceded by ITGCN.
Name 2 GCT types that are NOT preceded by ITGCN (choose from the 3 categories of infantile/prepubertal; adolescent/adult; spermatocytic seminoma) .
infantile/prepubertal; and SS
Example of intratubular germ cell neoplasia.
PAS stain + for abundant intracytoplasmic ----- in neoplastic cells
Isochromosomes of the ---- (short/long) arm of chromosome ----- is a consistent marker of all
Normal chromosomes have ---(#) long arm and --- short arm
Isochromosomes have either --- short arms or ---long arms (#)
What is the critical event that transforms ITGCN into invasive carcinoma?
MC type of testicular germ cell tumor (50%)
Seminomas are analogous to a -------tumor in the ovary.
-------- tumor is composed of sheets of uniform cells demarcated by lobules containing a moderate amount of lymphocytes.
Classic seminoma cell is large/round to polyhedral & has a distinct cell mb with abundant --- cytoplasm (color)
seminoma (note cluster of
cells + septa of fibrous tissue w/ lymphocytes)
Identify the testicular tumor
c-KIT and OCT 4 indicate ---- tumor
PLAP is associated with seminomas but also with ---------
spermatocytic seminomas are histologically similar to ------ spermatocytes
Which has the potential to metastasize- seminoma or spermatocytic seminoma?
3 cell types
: medium size cells predominate; giant cells and small lymphocyte-like cells)
seminoma or spermatocytic seminoma?
Which are reactive for PLAP- seminoma or spermatocytic seminoma?
which are + for VASA seminoma or spermatocytic seminoma?
Malignant ------ account for 2/3 of all non-seminomatous testicular cancers (choose embryonal; yolk sac; choriocarcinoma; teratoma)
All cases of non-seminomatous tumors have an isochromosome ----- (letter & number)
Which non-seminomatous GCT grows in alveolar/tubular patterns or w/ papillary convolutions? (yolk sac tumor, choriocarcinoma,embryonal carcinoma, or teratoma)
cytokeratin and CD30
are positive markers for embryonal carcinoma, yolk sac tumor, choriocarcinoma, or teratoma?
yolk sac tumor (note the
schiller duval body
in 2nd picture)
embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma
Schillar-Duval bodies are characteristic of:choriocarcinoma, and teratoma, embryonal carcinoma, yolk sac tumor ?
schiller duval bodies (mesodermal core with a central capillary surrounded by 2 layers)
This yolk sac tumor is demonstrating ---------
Choriocarcinoma carries a median survival of --- to ---- (time)
Which tumor contains both syncytiotrophoblasts AND cytotrophoblastic cells?
choriocarcinoma, and teratoma, embryonal carcinoma, yolk sac tumor ?
2 cell types
; recall SS has 3)
Prepubertal testicular teratomas derive from benign/malignant germ cells?
Postpubertal testicular teratomas derive from benign/malignant germ cells?
Prepubertal or postpubertal teratomas are almost always pure (not associated w/ other germ cell tumor elements)
Pre or postpubertal testicular teratomas usually have one or more additional germ cell tumor components?
Pre or post testicular teratomas display normal DNA and do not have isochromsome 12p
Which is associated with ITGNC? (pre or post pubertal testicular teratoma?)
+ hcG means presence of ------ cells (synciotrophoblast/yolk sac)
+AFP means --- elements are present (synciotrophoblast/yolk sac)
What cells form the sex cords? (sertoli or leydig?)
Which is more common- Leydig cell tumors or sertoli cell tumors?
Are Leydig cells hormonally active?
A hormonally active leydig cell means that an adult will experience- but a child will experience-----?
Leydig (note the polyhedral)
Sertoli or Leydig?
Crystals of Reinke
are pathogmnemonic for what type of tumor?
Leydig cell tumor
Leydig (Note Reinke's Crystals)
Identify - Leydig or Sertoli?
Leydig or Sertoli cell tumors present with hollow or solid tubules?
Both Sertoli & Leydig cell tumors are bi/unilateral?
-------- cell tumor of testis are well differentiated and have a prominent fibrous stroma with lobulated arrangement of tubules
Describe the "hormone" secretion factors of Leydig and Sertoli cell tumors?
(Leydig- hormonally functional; Sertoli is hormonly ((SI))lent)
Sertoli (note the tubes!)
What type of testicular tumor is this?
Direct derivative of ITGCN?
Embryonal CA will/will not invade tunica albuginea & shows foci of --- or ---
will invade TA; hemorrhage or necrosis
T/F: Embryonal CA
True (UNlike teratomas)
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