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5 Written questions

5 Matching questions

  1. DMARD clinical Uses
  2. Cytokines Effected by DMARDS
  3. Rituximab
  4. Sirolimus
  5. Abatacept
  1. a Leukemia/lymphoma Therapy
    MOA: CD20 binding, Blocks Ca2+ channel on B-cell
    Clinical Uses: CLL, B-cell lymphoma
  2. b IL-2
    TNF-a
    GM-CSF
    IL-3
    IL-4
    IL-5
    CXCL8
  3. c mTOR inhibitor
    MOA: Inhibits T-cell proliferation
    binds FKBP-12 and inhibits mTOR pathway
    Blocks IL-2 signalling
    Clinical Uses: prevention of renal transplant rejection
    Adverse Effects: Nephrotoxicity, Hypercholestrolemia, Hyper triglyceridemia, mylosuppression
  4. d prevention of acute allograft rejection
    Treatment of all inflammatory conditions
    Short-term anti-inflammatory
  5. e Soluable Ligand/Receptor Drugs
    MOA: Soluable CTLA4-Ig, competitive inhibitor of CD28
    prevents co-stimulatory CD80/86
    Prevents T-cell activation and cytokine release
    Clinical Uses: Treatment of Rheumatoid Arthritis

5 Multiple choice questions

  1. Leukemia/lymphoma therapy
    MOA: anti CD33 w/calicheamicin. Binds CD33+ cells Drug is internalized binds to DNA resulting in DNA double stranded breaks and cell death
  2. Soluable ligand/Receptor drugs
    MOA: TNF receptor Fc fusion protein, Binds soluable TNF, Blocks TNF
    Clinical Uses: Used for Rheumatoid Arthritis, Crohn's Disease, Ulcerative Colitis, Psoriasis
  3. Aspirin
    Ibuprophen
    Naproxene
    Celecoxib
  4. DNA-Alkylating Agent
    Clinical Uses: prevention/reversal and reversal of graft rejection
    Treatment of auto-immune disease
    SLE
    Myasthenia Gravis
  5. Immunosupressant
    MOA: IgE antagonist
    Clinical Uses: Asthma

5 True/False questions

  1. DMARD Toxcitiesinhibits transcription of inflammatory mediators
    Increase some anti-inflammatory regulator genes
    Decrease production of cytokines
    Reduced expression of adhesion molecules =decreased leukocyte adhesion

          

  2. Ankinrainhibits transcription of inflammatory mediators
    Increase some anti-inflammatory regulator genes
    Decrease production of cytokines
    Reduced expression of adhesion molecules =decreased leukocyte adhesion

          

  3. Calcineurin Inhibitors MOAprevent Ca2+ binding to calcineurin
    black signal transduction pathway
    Prevents IL-2 produciton
    Prevents T-cell proliferation
    B cell phagocyte function spared

          

  4. MethotrexateSoluable ligand/Receptor drugs
    MOA: TNF receptor Fc fusion protein, Binds soluable TNF, Blocks TNF
    Clinical Uses: Used for Rheumatoid Arthritis, Crohn's Disease, Ulcerative Colitis, Psoriasis

          

  5. InfliximabLeukemia/lymphoma Therapy
    MOA: CD20 binding, Blocks Ca2+ channel on B-cell
    Clinical Uses: CLL, B-cell lymphoma

          

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