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5 Written questions

5 Matching questions

  1. NSAIDS MOA
  2. NSAIDS clinical Uses
  3. Infliximab
  4. Rituximab
  5. Chlorambucil
  1. a Inflammatory conditions
    Not for transplantation
  2. b TNF antagonist
    Immunosuppresant
    MOA: TNF targeting
    Clinical Uses: Crohns disease, RA, Ulcerative Colitis,
  3. c Leukemia/lymphoma Therapy
    MOA: CD20 binding, Blocks Ca2+ channel on B-cell
    Clinical Uses: CLL, B-cell lymphoma
  4. d DNA-Alkylating Agent
    Clinical Uses: prevention/reversal and reversal of graft rejection
    Treatment of auto-immune disease
    SLE
    Myasthenia Gravis
  5. e reduce inflammation
    target non-specifc inflammtory cells
    overlapping therapuetic goals
    Not-immunosuppressive
    inhibits PG synthesis
    inhibits COX1/COX2 activity
    no effect on T/B cells

5 Multiple choice questions

  1. Cytotoxic Drug
    MOA: Folic acid antagoinst
    Clinical Uses: Rheumatoid arthritis Gold standard drug
  2. Lymphocyte Trafficking Inhibitors
    MOA:alpha-4 integrin blocks vascular adhesion molecuels prevents T lymphocyte entry into brain or gut
    Clinical Uses: Relapsing MS, Crohns Disease
    Adverse Effects: Risk ofr multi focal leukoencephalopathy
  3. Soluable ligand/Receptor drugs
    MOA: TNF receptor Fc fusion protein, Binds soluable TNF, Blocks TNF
    Clinical Uses: Used for Rheumatoid Arthritis, Crohn's Disease, Ulcerative Colitis, Psoriasis
  4. prevent Ca2+ binding to calcineurin
    black signal transduction pathway
    Prevents IL-2 produciton
    Prevents T-cell proliferation
    B cell phagocyte function spared
  5. IL-1 cytokine antagonist
    Soluable Ligand Receptor Drugs
    MOA: sIL1 receptor antagonist
    Clinical Uses: RA

5 True/False questions

  1. DexamethasoneCorticosteroid
    Immunosuppressant
    Long-action
    MOA: DMARD
    Tox: DMARD

          

  2. AbataceptSoluable ligand/Receptor drugs
    MOA: TNF receptor Fc fusion protein, Binds soluable TNF, Blocks TNF
    Clinical Uses: Used for Rheumatoid Arthritis, Crohn's Disease, Ulcerative Colitis, Psoriasis

          

  3. DaclizumabImmunosuppresant for Organ Transplantation
    MOA: IL2r, CD25
    Clinical Uses: Allograft rejection
    GVHD

          

  4. DMARD clinical Usesprevention of acute allograft rejection
    Treatment of all inflammatory conditions
    Short-term anti-inflammatory

          

  5. AzthioprinePurine Antagonist
    MOA: pro-drug 6-mercaptopurine
    Clinical Uses: Tx of Rheumatoid Arthritis Anti-inflammatory, graft rejection
    Adverse Effects: Myelosuppression, Dose dependent, Neutropenia, thrombocytopenia
    Contra-Indication: current infection
    pancreatitis

          

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