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5 Written questions

5 Matching questions

  1. Tacrolimus
  2. Prednisone
  3. NSAIDS clinical Uses
  4. Mycophenolate Mofetil
  5. Methotrexate
  1. a Cytotoxic Drug
    MOA: Folic acid antagoinst
    Clinical Uses: Rheumatoid arthritis Gold standard drug
  2. b MOA: MMF converted in-vivo to mycophenolic acid
    Inhibits T/B cell proliferation
    Prevents DNA synthesis by inhibiting IMP-DH prevents guanosine nucleotide production
    Clinical Uses: Prevention of GVHD
    graft rejection
    Lupus nephritis
    Toxcities: Diarrhea, vomitting, nausea, meylosupression
    Contraindication: Hepatic Insufficiency
  3. c Calcineurin Inhibitor
    MOA: binds FK protein inhibits IL-2 Secretion and other cytokines
    Clinical Use: Prevention/Rejection of organ transplantation
    Toxcities: Nephrotoxic, Diabetes, peripheral neuropathy
  4. d Corticosteroid
    MOA: converted in-vivo to prednisolone
    DMARD Tox
  5. e Inflammatory conditions
    Not for transplantation

5 Multiple choice questions

  1. mTOR inhibitor
    MOA: Inhibits T-cell proliferation
    binds FKBP-12 and inhibits mTOR pathway
    Blocks IL-2 signalling
    Clinical Uses: prevention of renal transplant rejection
    Adverse Effects: Nephrotoxicity, Hypercholestrolemia, Hyper triglyceridemia, mylosuppression
  2. Immunosuppresant for Organ Transplantation
    MOA: IL2r, CD25
    Clinical Uses: Allograft rejection
  3. Soluable Ligand/Receptor Drugs
    MOA: Soluable CTLA4-Ig, competitive inhibitor of CD28
    prevents co-stimulatory CD80/86
    Prevents T-cell activation and cytokine release
    Clinical Uses: Treatment of Rheumatoid Arthritis
  4. Leukemia/lymphoma Therapy
    MOA: CD20 binding, Blocks Ca2+ channel on B-cell
    Clinical Uses: CLL, B-cell lymphoma
  5. TNF antagonist
    MOA: TNF targeting
    Clinical Uses: Crohns disease, RA, Ulcerative Colitis,

5 True/False questions

  1. TrastuzumabLeukemia/lymphoma therapy
    MOA: anti CD33 w/calicheamicin. Binds CD33+ cells Drug is internalized binds to DNA resulting in DNA double stranded breaks and cell death


  2. Calcineurin Inhibitors MOAprevent Ca2+ binding to calcineurin
    black signal transduction pathway
    Prevents IL-2 produciton
    Prevents T-cell proliferation
    B cell phagocyte function spared


  3. CyclophosphamideDNA-Alkylating Agent
    Clinical Uses: prevention/reversal and reversal of graft rejection
    Treatment of auto-immune disease
    Myasthenia Gravis


  4. DMARD ToxcitiesOsteoporosis
    Cushingoid appearance
    impaired glucose metab
    cataract glaucoma
    Skin thinning


  5. NSAIDS MOAinhibits transcription of inflammatory mediators
    Increase some anti-inflammatory regulator genes
    Decrease production of cytokines
    Reduced expression of adhesion molecules =decreased leukocyte adhesion