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5 Written questions

5 Matching questions

  1. Ankinra
  2. Fingolimod
  3. Azthioprine
  4. Gemtuzumab
  5. Infliximab
  1. a IL-1 cytokine antagonist
    Soluable Ligand Receptor Drugs
    MOA: sIL1 receptor antagonist
    Clinical Uses: RA
  2. b TNF antagonist
    Immunosuppresant
    MOA: TNF targeting
    Clinical Uses: Crohns disease, RA, Ulcerative Colitis,
  3. c Leukemia/lymphoma therapy
    MOA: anti CD33 w/calicheamicin. Binds CD33+ cells Drug is internalized binds to DNA resulting in DNA double stranded breaks and cell death
  4. d Purine Antagonist
    MOA: pro-drug 6-mercaptopurine
    Clinical Uses: Tx of Rheumatoid Arthritis Anti-inflammatory, graft rejection
    Adverse Effects: Myelosuppression, Dose dependent, Neutropenia, thrombocytopenia
    Contra-Indication: current infection
    pancreatitis
  5. e Lymphocyte Trafficking Inhibitors
    MOA: Prodrug, Phosphorylated by sphingosine kinase
    Blocks lymphocyte from exiting lymph nodes causes lymphopenia
    Targets CD4>CD8>b-cells
    Clinical Uses: Relapsing MS, Taken Orally
    Adverse Effect: Bradycardia, Opportunistic infections

5 Multiple choice questions

  1. Cancer Treatment
    MOA: HER2/neu, Growth Factor receptor
    Clical Uses: Breast Cancer
  2. inhibits transcription of inflammatory mediators
    Increase some anti-inflammatory regulator genes
    Decrease production of cytokines
    Reduced expression of adhesion molecules =decreased leukocyte adhesion
  3. prevent Ca2+ binding to calcineurin
    black signal transduction pathway
    Prevents IL-2 produciton
    Prevents T-cell proliferation
    B cell phagocyte function spared
  4. Aspirin
    Ibuprophen
    Naproxene
    Celecoxib
  5. Leukemia/lymphoma Therapy
    MOA: CD20 binding, Blocks Ca2+ channel on B-cell
    Clinical Uses: CLL, B-cell lymphoma

5 True/False questions

  1. NatalizumabImmunosupressant
    MOA: IgE antagonist
    Clinical Uses: Asthma

          

  2. DexamethasoneCorticosteroid
    Immunosuppressant
    Long-action
    MOA: DMARD
    Tox: DMARD

          

  3. CyclophosphamideDNA-Alkylating Agent
    Clinical Uses: prevention/reversal and reversal of graft rejection
    Treatment of auto-immune disease
    SLE
    Myasthenia Gravis

          

  4. AbataceptSoluable ligand/Receptor drugs
    MOA: TNF receptor Fc fusion protein, Binds soluable TNF, Blocks TNF
    Clinical Uses: Used for Rheumatoid Arthritis, Crohn's Disease, Ulcerative Colitis, Psoriasis

          

  5. OmalizumabLymphocyte Trafficking Inhibitors
    MOA:alpha-4 integrin blocks vascular adhesion molecuels prevents T lymphocyte entry into brain or gut
    Clinical Uses: Relapsing MS, Crohns Disease
    Adverse Effects: Risk ofr multi focal leukoencephalopathy