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5 Written questions

5 Matching questions

  1. Chlorambucil
  2. NSAID Drugs
  3. Cyclosporin
  4. Methotrexate
  5. Omalizumab
  1. a Aspirin
    Ibuprophen
    Naproxene
    Celecoxib
  2. b Immunosupressant
    MOA: IgE antagonist
    Clinical Uses: Asthma
  3. c Cytotoxic Drug
    MOA: Folic acid antagoinst
    Clinical Uses: Rheumatoid arthritis Gold standard drug
  4. d Calcineurin Inhibitor
    MOA: prevents IL2/IL-2 receptor production
    Clinical Uses: prevetion of graft rejection, not reverse graft rejection
    Tox: Reversible B-lympoproliferatie disorders, Nephrotoxic
  5. e DNA-Alkylating Agent
    Clinical Uses: prevention/reversal and reversal of graft rejection
    Treatment of auto-immune disease
    SLE
    Myasthenia Gravis

5 Multiple choice questions

  1. Corticosteroid
    Immunosuppressant
    Short-duration
    MOA: converted in-vivo to prednisolone
    DMARD Tox
  2. MOA: MMF converted in-vivo to mycophenolic acid
    Inhibits T/B cell proliferation
    Prevents DNA synthesis by inhibiting IMP-DH prevents guanosine nucleotide production
    Clinical Uses: Prevention of GVHD
    graft rejection
    Lupus nephritis
    Toxcities: Diarrhea, vomitting, nausea, meylosupression
    Contraindication: Hepatic Insufficiency
  3. Lymphocyte Trafficking Inhibitors
    MOA: Prodrug, Phosphorylated by sphingosine kinase
    Blocks lymphocyte from exiting lymph nodes causes lymphopenia
    Targets CD4>CD8>b-cells
    Clinical Uses: Relapsing MS, Taken Orally
    Adverse Effect: Bradycardia, Opportunistic infections
  4. Purine Antagonist
    MOA: pro-drug 6-mercaptopurine
    Clinical Uses: Tx of Rheumatoid Arthritis Anti-inflammatory, graft rejection
    Adverse Effects: Myelosuppression, Dose dependent, Neutropenia, thrombocytopenia
    Contra-Indication: current infection
    pancreatitis
  5. Corticosteroid
    Immunosuppressant
    Long-action
    MOA: DMARD
    Tox: DMARD

5 True/False questions

  1. GemtuzumabLeukemia/lymphoma therapy
    MOA: anti CD33 w/calicheamicin. Binds CD33+ cells Drug is internalized binds to DNA resulting in DNA double stranded breaks and cell death

          

  2. AnkinraIL-1 cytokine antagonist
    Soluable Ligand Receptor Drugs
    MOA: sIL1 receptor antagonist
    Clinical Uses: RA

          

  3. TrastuzumabLeukemia/lymphoma therapy
    MOA: anti CD33 w/calicheamicin. Binds CD33+ cells Drug is internalized binds to DNA resulting in DNA double stranded breaks and cell death

          

  4. CyclophosphamideDNA-Alkylating Agent
    Clinical Uses: prevention/reversal and reversal of graft rejection
    Treatment of auto-immune disease
    SLE
    Myasthenia Gravis

          

  5. SirolimusmTOR inhibitor
    MOA: Inhibits T-cell proliferation
    binds FKBP-12 and inhibits mTOR pathway
    Blocks IL-2 signalling
    Clinical Uses: prevention of renal transplant rejection
    Adverse Effects: Nephrotoxicity, Hypercholestrolemia, Hyper triglyceridemia, mylosuppression