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5 Written questions

5 Matching questions

  1. Rituximab
  2. Fingolimod
  3. Gemtuzumab
  4. Calcineurin Inhibitors MOA
  5. Cyclophosphamide
  1. a Leukemia/lymphoma therapy
    MOA: anti CD33 w/calicheamicin. Binds CD33+ cells Drug is internalized binds to DNA resulting in DNA double stranded breaks and cell death
  2. b DNA-Alkylating Agent
    Clinical Uses: prevention/reversal and reversal of graft rejection
    Treatment of auto-immune disease
    SLE
    Myasthenia Gravis
  3. c Leukemia/lymphoma Therapy
    MOA: CD20 binding, Blocks Ca2+ channel on B-cell
    Clinical Uses: CLL, B-cell lymphoma
  4. d prevent Ca2+ binding to calcineurin
    black signal transduction pathway
    Prevents IL-2 produciton
    Prevents T-cell proliferation
    B cell phagocyte function spared
  5. e Lymphocyte Trafficking Inhibitors
    MOA: Prodrug, Phosphorylated by sphingosine kinase
    Blocks lymphocyte from exiting lymph nodes causes lymphopenia
    Targets CD4>CD8>b-cells
    Clinical Uses: Relapsing MS, Taken Orally
    Adverse Effect: Bradycardia, Opportunistic infections

5 Multiple choice questions

  1. MOA: MMF converted in-vivo to mycophenolic acid
    Inhibits T/B cell proliferation
    Prevents DNA synthesis by inhibiting IMP-DH prevents guanosine nucleotide production
    Clinical Uses: Prevention of GVHD
    graft rejection
    Lupus nephritis
    Toxcities: Diarrhea, vomitting, nausea, meylosupression
    Contraindication: Hepatic Insufficiency
  2. Cytotoxic Drug
    MOA: Folic acid antagoinst
    Clinical Uses: Rheumatoid arthritis Gold standard drug
  3. DNA-Alkylating Agent
    Clinical Uses: prevention/reversal and reversal of graft rejection
    Treatment of auto-immune disease
    SLE
    Myasthenia Gravis
  4. IL-1 cytokine antagonist
    Soluable Ligand Receptor Drugs
    MOA: sIL1 receptor antagonist
    Clinical Uses: RA
  5. Purine Antagonist
    MOA: pro-drug 6-mercaptopurine
    Clinical Uses: Tx of Rheumatoid Arthritis Anti-inflammatory, graft rejection
    Adverse Effects: Myelosuppression, Dose dependent, Neutropenia, thrombocytopenia
    Contra-Indication: current infection
    pancreatitis

5 True/False questions

  1. Cytokines Effected by DMARDSIL-2
    TNF-a
    GM-CSF
    IL-3
    IL-4
    IL-5
    CXCL8

          

  2. DenileukinIL-1 cytokine antagonist
    Soluable Ligand Receptor Drugs
    MOA: sIL1 receptor antagonist
    Clinical Uses: RA

          

  3. PrednisoneCorticosteroid
    Immunosuppressant
    Long-action
    MOA: DMARD
    Tox: DMARD

          

  4. NSAID DrugsAspirin
    Ibuprophen
    Naproxene
    Celecoxib

          

  5. NSAIDS MOAinhibits transcription of inflammatory mediators
    Increase some anti-inflammatory regulator genes
    Decrease production of cytokines
    Reduced expression of adhesion molecules =decreased leukocyte adhesion