- Tinea versicolor (Malassezia furfur), pedis (foot), cruris (groin), corporis (ringworm, on body), capitis (head, scalp), unguium (onychomycosis, on fingernails).
- Pruritic lesions with central clearance resembling a ring, caused by dermatophytes (Microsporum, Trichophyton, and Epidermophyton). --> mold hyphae in KOH prep are not dimorphic
- All DNA viruses except the Parvoviridae are dsDNA.
- All are linear except papilloma-, polyoma- (these two are circular, supercoiled), and hepadnavriuses (circular, incomplete).
- All are dsDNA (like our cells), except "part of a virus" (parvovirus) is DNA
- All DNA virus are icosahedral.
- Parvus = small
- DNA viruses = all replicate in the nucleus (except poxvirus).
- HHAPPPPy viruses
Hepadna, Herpes, Adeno, Parvo, Pox, Polyoma, Papilloma
Family: Picornaviridae, +ssRNA, naked, 4 genotypes but only one serotype, limited host range (primates)
Transmission: enteric (fecal-oral)
Characteristics: very resistant viruses (survives for days to weeks in the GI pH); in developed countries, it is seen in traveler's returning from endemic regions
Risk Factors: link to poor SES, consumption of shellfish, contaminated water, different types of sexual contact, institutional workers, IVDA
Incubation Period: 2-7 weeks
Duration (Acute Phase): 8-12 weeks
Cytopathic effects: Little
Immunopathogenesis: Cell-mediated (specific CD 8 cells, NK cells) hepatocyte damage; infection with HAV most likely provides lifelong immunity
Prevention & Control: hygiene, vaccination (formalin-activated adjuvented whole virus vaccines given to children older than 1 year of age; requires a booster shot 6-12 months after booster dose for lifelong protection)
Regeneration and liver functions usually return to normal within 8-12 weeks.