What type of connective tissue proper does not have a lot of structural rigidity nor abundant fibers?
What type of connective tissue proper is found in hypodermis of skin and under surface epithelia of respiratory system and GI tract?
Dense (regular and irregular)
What type of connective tissue proper has a much higher concentration of fibers than loose, connective tissue?
What type of connective tissue proper has tight bundled structures with fibers that tend to line up in parallel to provide strength?
What type of connective tissue proper is commonly found in ligaments and tendons?
What type of connective tissue proper has a random arrangement of fibers?
What type of connective tissue proper is commonly found in the dermis of skin, sheaths of tendons and nerves, and capsules of many organs?
What are largely responsible for influencing the alignment of collagen fibers?
What type of connective tissue proper is composed of type III collagen fibers?
What type of connective tissue proper is commonly found in lympathic organs?
What type of connective tissue proper often form sheets of fat cells?
What type of connective tissue proper is often found in loose areolar connective tissue?
What type of connective tissue proper is commonly found surrounding kidney and adrenal glands?
What type of connective tissue proper has abundant extracellular fibrous tissue?
What type of connective tissue proper is more elastic and found in large arteries and the trachea?
What type of connective tissue proper is found within the umbilical cord?
What type of cells end up remaining in the general area where they originated?
Fibroblast is a type of (fixed/wandering) cell.
What type of cells originate locally from undifferentiated mesenchymal cells and spend their life in connective tissue?
What type of cells are responsible for providing almost all components within the ECM?
What type of cells are the most common cell in connective tissue?
What type of cells synthesize GAGs, elastin, collagen, and proteoglycans?
What type of cells synthesize multi-adhesive glycoproteins, like laminin and fibronectin?
What term is given to quiescent fibroblasts?
What type of adipose is unilocular for the lipid droplet?
What type of adipose has several similar-sized lipid droplets and lots of mitochondria?
Which adipose tissue plays a role in thermoregulation for newborns and hibernating animals?
Which adipose is physiologically geared toward creating non-shivering heat but is not very abundant in adult humans?
What type of cells are brought into connective tissue by the blood vascular system?
What type of cells are leukocytes?
Where do macrophages arise?
What type of cells are mast cells?
What is the active process of cells moving from the blood vascular system into the connective tissue?
What process is the progression of cells from inside the blood vascular system to outside in to the connective tissue?
What are the only cells that may return to the blood vascular system from the connective tissue?
What kind of stem cells are cells that arise from the bone marrow?
Which cells have a eccentrically placed nucleus with a clock-face appearance?
Which cells arise from activated B lymphocytes and produce/secrete antibodies?
In plasma cells, juxtanuclear clear areas account for which organelle not taking up stain?
Which cells are prevalent in areas prone to infection?
Which cells have an eccentric nucleus and act as defense elements?
Which cells present antigen that they have partially digested to stimulate an immune response?
What is a type of macrophage that can be found at the base of the lungs?
Which cells are large with a central nucleus?
Which cells stimulate immediate hypersensitivity response?
Which cells demonstrate metachromasia due to acidic radical content?
Which cells induce anaphylaxis?
What is the massive, sudden release of a lot of potent factors from the mast cells?
What is characterized by the contraction of smooth muscle and dilation of a lot of fluid from the capillaries due to release of pharmacologically active substances?
Provide a hydrated gel, which resists compressive forces.
Consists of a glycosoaminoglycan (GAG) bounded to a protein core.
What is a dominant ECM proteoglycan aggregate in cartilage?
Which protein tends to be prevalent in structures such as the interior of the eye or cartilage?
Which protein attracts sodium ions and water?
What mediates the transmembrane linkage of ECM components and actin?
What is anchored inside the cell to the cytoskeleton and externally via fibronectin to the ECM?
What kind of GAG binds a lot of water and can become an aggregate serving as a good model for compressive forces?
Proteoglycans have (rapid/slow) turnover rates.
A series of genetic disorders characterized by the inability to break down proteoglycans.
What is a cofactor for proline hydroxylase?
Lysine and proline
Which amino acids are hydroxylated during collagen synthesis?
Which type of collagen composes bones and tendons?
Which type of collagen composes reticular fibers?
Which type of collagen composes the basement membrane (attaches to integrins)?
Which type of collagen participates in type I collagen function?
Final assemblage of collagen takes place (outside/inside) the cell.
How does pro-collagen get secreted?
What is a deficiency of connective tissue that may cause teeth to fall out?
What syndrome is associated with collagen synthesis problems?
Collagen type III
Ehlers-Danlos Syndrome type 4 is associated with what deficiency?
What is characterized by ruptures in arteries and the intestine? (Both structures are rich in reticular fibers)
Which type of Ehlers-Danlos Syndrome is associated with cutis hyperelastica?
T/F: Arygophilic fibers are the only type of collagen that will stain with silver salts.
False (They ARE!!)
T/F: Reticular fibers are not arygophilic.
Common type of fibers in lymph nodes and spleen.
Elastin and fibrilin
What are the two major proteins of elastic fibers?
What protein is necessary for elastin deposition ?
What gene is most important for fibrilin?
A defect in the FBN-1 gene results in what?
What defect is characterized by hyperelastic joints and long arms/fingers?
False (fibroblasts are derived from undifferentiated mesenchymal cells and are grouped with the fixed cells along with adipocytes, chondroblasts and osteoblasts.)
T/F Wandering cells are those derived from hematopoetic stem cells such as mast cells, red blood cells, fibroblasts, lymphocytes, and monocytes.
These cells are capable of phagocytosis and are usually first to arrive to an area of inflammation. They are responsible for control of a bacterial infection
What protein is responsible for attachment of the cell to extracellular matrix?
Type IV collagen and laminin
What makes up the basement membrane?
LOOK AT: Formation of a collagen fibril