hereditary motor and sensory neuropathy type 1 (Charcot-Marie-Tooth)
AD disorder presents in childhood or early adulthood with progressive muscular atrophy of the leg below the knee +/- problems of the foot. heterogeneous inheritance associated with mutations in PMP22, CX32, MPZ, PRX, and MBP (myelin-associated genes). morphology shows onion bulbs, enlargement of periph nerves, degeneration of posterior columns. normal life span.