Create an account
hormone: glycoprot, dec PO2 -> fibroblasts secrete in renal interstitium -> inc RBCs => people w/ renal failure dev anemia
15% of nephrons, have a long LOH + vasa recta, have greater filtration, reabs, "salt-conserving"
RBF (renal blood flow)
Upah*V/Apah, est w/ PAH, 20% CO = 1L/minute = 350mL/minute/100g, which is 7x that of brain
GFR (glomerular filtration rate)
Puf Kuf = ultrafiltration P ultrafiltration coeff, Kuf = permability * SA, est w/ Insulin or Creatinine
GFR autoreg: distend afferent arteriole -> open non-spec cation chans -> depol -> VGCa2+ open -> contract smooth mm -> inc R -> restore Q to norm
TGF (tubuloglomerular feedback)
GFR autoreg: inc NaCl to macula densa (how it senses inc flow) -> inc ATP -> adenosine -> A1 on afferent arteriole -> vasoconstrict
UxV/Px = volume of plasma rendered free of a subst in 1 min = amt subst per min / subst in pl
clinical: mut NKCC2, ROMK, or CLC-Kb of TALH -> waste NaCl, lose lots of Ca2+ + Mg
drug: diuretics that act on Na/Cl cotransporter of DCT, inc Ca2+ reabs -> hypercalcemia, kyperkalemia
inc Na+ reabs in TALH by inc NKCC2, ROMK, cation transport, imp for countercurrent mult sys
inc Na+ reabs in principal cell of CD by inc ENaC, ROMK, NA/K ATPase => also inc K+ secr
ADH receptor for water retention on TALH, CD -> inc cAMP, ins AQP2 vesicles into apical memb, inc transporters (NKCC2, ROMK)
clinical: bad ADH reg -> polydipsia, polyuria, Central = PosPit ADH rel prob, Nephrogenic = kidney V2 prob, Psychogenic = mental prob
second most abund intracellular cation (after K+), 65% reabs in LoH, 25% in PT (reverse of Na+ + Ca2+ handling)
CaR (extracellular Ca2+ sensing Receptor)
senses fall in [Ca2+]free, ionized -> G protein -> PTh -> PTH
# mols of strong acid in 1 L of sltn to reduce pH by 1 OR mols of strong B added to 1 L of sltn to inc pH by 1
NBC (Na Bicarbonate Cotransporter)
Na+ + 3 HCO3- cotransporter on basolateral PCT memb, uses HCO30 from action of cyto CA
cells in CD that have apical Cl-/HCO3- exchangers active in response to inc pH, minor fx in rel to amt of HCO3- that is reabs, filtered, or created
amt of strong HA or B (mEq/L) to titrate pH of 100% ox bl to 7.4 @ 37 dec C @ 40mm Hg, norm range = -2 to + +2, (<-2 = metab acidosis, > +2 = metab alkalosis)
[Na+] - ([Cl-] + [HCO3-]), norm = 8-16mmol/L (> 18 = unmeas anions, oft in metabolic acidosis), metab acidosis w/ norm anion gap found in hyperchloremia (due to HCO3-/Cl- exch)
Please allow access to your computer’s microphone to use Voice Recording.
Having trouble? Click here for help.
We can’t access your microphone!
Click the icon above to update your browser permissions and try again
Reload the page to try again!Reload
Press Cmd-0 to reset your zoom
Press Ctrl-0 to reset your zoom
It looks like your browser might be zoomed in or out. Your browser needs to be zoomed to a normal size to record audio.
Please upgrade Flash or install Chrome
to use Voice Recording.
For more help, see our troubleshooting page.
Your microphone is muted
For help fixing this issue, see this FAQ.
Star this term
You can study starred terms together