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Mutations can be induced by exposing organisms (or cells) to a variety of treatments.
Can bend to DNA or the building blocks of DNA and interfare with the replication of transcription process.
Other Genetic Changes
Allerant cell division resulting incorrect division of the chromosomes can lead to ANEUPLOIDY. Viruses can cause genetic damage in several different ways and area associated with a wide range of CANCERS.
Are DNA reactive chemicals. Involve direct modification of DNA. can lead to mutations-most-but not all cancers produce mutations.
Agents which lack of evidence of direct of DNA. Have indirect effect on genome through interacting with other cellular molecular such as mamalian DNA polymerase interaction of carcinogens with DNA polymerase causes loss of its fidelity leading to entrenouss sequencing mutations and cancer.
In humans it induced leukemia caused by organophosphate; saccann, plastics, bile salts etc.
Most carcinogens react covalently with tissue macromolecules by this (methylation, ethylation, etc.)
Contains an electrophilic (electron difficient atom) atom whom reacts with a nuclephilic (electron non) atom such as GSH
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