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EEOB Final Exam

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Gene which causes Achrondroplasia
FGF3R
FGF3R gene
usually involved in the regulation and development of bones and the brain
FGF3R gene function
encodes the protein for the the fibroblast growth factor receptor which spans the cell membrane
FGF3R bone function
In bone growth the protein helps regulate how chondrocytes develop and calcify
FGF3R mutation
a glycine is replaced with an arginine, this causes the receptor to be overly active
mouse ephysial plate
The main characteristic of a mouse with achondroplasia is an underdeveloped hypertrophic zone in the epiphyseal plate. This condition disrupts the normal growth of long bones due to the fact that achondroplasia only disrupts endochondral ossification
human ovary
oocytes are made and mature here
oocyte
surronded by granulosa and and follicle
human oviducts
after the ovaries, has a mucosa layer and ciliated cells
uterus (human)
has mucosa, smooth muscle, and outer connective tissue layer
Cervix
divides uterus and vagina, outer ring of smooth muscle
Vagina
A muscular, elastic passageway that extends from the uterus to the outside of the body, has squamous epithelium
Chicken Ovary
made up of masses of rounded follicles each containing an ovum/yolk
infundibulum
where the yolk is deposited, and fertilized
magnum
Where a dense portion of the albumen is added
isthmus
where the shell membrane is added, determines shape of the egg
uterus (chicken)
where the rest of the albumen is added, and the shell is formed
shell
made of calcium carbonate
vagina (chicken)
egg is pushed out, contains the sperm host gland
Symptoms of ARMD
visual distortions, straight lines seeming bent, reduced central vision, a blind spit in your vision
Dry ARMD
-more common form of macular degeneration
-small yellowish deposits (drusen) develop on the macula and interfere with central vision
-drusen are dried retinal pigment epithelial cells that form granules on the macula
-rarely leads to total blindness
Wet ARMD
Also called neovascular

Abnormal blood vessels grow under the macula, causing its displacement

Affects central vision

Progression can be rapid with resultant blindness within 2 years
choroid
middle, vascular layer of the eye, between the retina and the sclera
abnormal blood vessels
leaky due to lack of tight junctions
bump in macula
leads to visual distortions, swelling, and eventually blindness