carboplatin
- ototox = reversible
- BBW = vomiting, bone marrow suppression
- causes N/V if pre-tx w/ emetogenic
cisplatin
- ototox = permanent
- BBW = ototox, renal tox, med safety (max dose/cycle)
- requires tx of N/V b/f tx b/c it's a potent emotogenic drug
- neurotoxicity, light sensitivity, ↓ eletrolytes