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Anti-Tuberculosis TB Drugs 1-31

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Specify the first line drugs for the treatment of tuberculosis (TB)

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Terms in this set (17)

Specify the first line drugs for the treatment of tuberculosis (TB)

Rifampin
Isoniazid
Pyrazinamide
Ethambutol
-95% cure rate in 6mo & coverage for RIF & INH resistance

identify the preferred agent for treatment of a latent TB infection.

Name the drug used as an
alternative to treat a latent TB infection

State the recommended Initial Therapy and Continuation Therapy for the treatment of an active TB infection in the general population

Izoniazid (INH) + Rifampin + Pyrazinamide + Ethambutol (2months) -> INH + RIF (4 months, if no drug resistance)

Explain why combination drug therapy for a prolonged period is necessary for effective treatment of tuberculosis

Organism grows slowly
Drug therapy typically requires 6 months but may require up to 2 years in some pt populations

Can be dormant
- May be completely resistant or killed only very slowly

Lipid-rich cell wall (restricts entry of some drugs)
Infection can reside within host cells (drug may penetrate host cell poorly)