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Atorvastatin (Lipitor)

Simvastatin (Zocor)

Therapeutic Class?

Pharmacologic Class?

T: Lipid-Lowering Agents

P: HMG-CoA Reductase Inhibitors "Statins"

Atorvastatin (Lipitor)

Simvastatin (Zocor)

Main Action

Prevents synthesis of cholesterol by the liver.

Atorvastatin (Lipitor)

Simvastatin (Zocor)


Elevated LDLs.

Atorvastatin (Lipitor)

Simvastatin (Zocor)

Side Effect/Adverse Reaction

Liver toxicity, Gl disturbances, rhabdomyolysis.

Atorvastatin (Lipitor)

Simvastatin (Zocor)


Monitor for diarrhea and constipation, muscle pain and weakness; some may need to be given with evening meal to decrease Gl upset.

Atorvastatin (Lipitor)

Simvastatin (Zocor)

Patient Teaching

Do not eat grapefruit.

Report muscle aches and dark colored urine.

Have periodic liver function tests.

Do not take if pregnant or breast feeding.

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