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activated monocytes that leave the blood and enter infected tissue. They become large once activated
Toll like receptors help with
differentiating different types of viruses and trigger cytokine production appropriate to the type of infection (intracellular vs extracellular bacteria infections.
What happens when toll like receptors are activated
they transmit signal to activate gene expression.
What happens when APC's are activated
1.Can now digest and kill pathogen. 2.Can now express and secrete cytokine (IL1,TNF,IL12). 3. Upregulatecell surface receptors to enhance display of pathogenic antigens
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