3 types of phagocytes
neutrophils monocytes dendritic
activated monocytes that leave the blood and enter infected tissue. They become large once activated
abundant and first cells to enter infected tissues
very potent activator of immune response. mature cells reside in tissues and organs
Immature dendritic cells are found
in the blood
Toll like receptors help with
differentiating different types of viruses and trigger cytokine production appropriate to the type of infection (intracellular vs extracellular bacteria infections.
What happens when toll like receptors are activated
they transmit signal to activate gene expression.
What happens when APC's are activated
1.Can now digest and kill pathogen. 2.Can now express and secrete cytokine (IL1,TNF,IL12). 3. Upregulatecell surface receptors to enhance display of pathogenic antigens
what is pseuodopia
long membrane invaginations
what is a phagosome
vacuole with pathogen inside
what is a phagolysosome
its when a phagosom and a lysosome fuse
What does a phagocyte do after digesting a pathogen
release digestion products from the cell.