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36 terms

Oncology

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Doxorubicin
Adriamycin

Anthracycline
Capecitabine
Xeloda

Antimetabolite
Gemcitabine
Gemzar

Antimetabolite
Paclitaxel
Taxol

Taxane
Docetaxel
Taxotere

Taxane
Topotecan
Hycamtin

Camptothecins
Irinotecan
Camptosar

Camptothecins
Oxaliplatin
Eloxatin

Platinum Compound
Bicalutamide
Casodex

Antiandrogen
Anastrozole
Arimidex

Aromatase Inhibitor
Letrozole
Femara

Aromatase Inhibitor
Erlotinib
Tarceva

EGFR-tyrosine kinase inhibitor
Imatinib
Gleevec

Tyrosine kinase inhibitor
Trastuzumab
Herceptin

Monoclonal Antibody
Bevacizumab
Avastin

Monoclonal Antibody
Rituximab
Rituxan

Monoclonal Antibody
Vinorelbine
Navelbine

Vinca Alkaloid
Leuprolide
Lupron

LHRH agonist
Goserelin
Zoladex

LHRH agonist
Alkylating Agent
Non-Specific

Alkylation of DNA
Antitumor Abx (Anthracycline)
Non-Specific

Binds to DNA, Inhibits RNA synthesis
Antimetabolites
S-Phase

Similar to normal cell substances & when incorporated in cell, makes cell unable to divide
Camptothecins
S-Phase

Topoisomerase I inhibitor (causing DNA breakage)
Epipodophyhllotoxins
G2 & S-Phase

Topoisomerase II inhibitor (causing DNA breakage)
Taxanes
G2 & M Phase

Antimicrotubular agent, inhibits mitosis by interfering with the microtubules, which help move chromosomes during mitosis
Vinca alkaloids
G2 & M phase

Antimicrotubular agent as above
Antiestrogens
Bind to estrogen receptors on tumor surface to prevent cell growth/cause cell death
Aromatase Inhibitors
Block aromatase enzyme, which converts androgens to estrogen causing tumors to shrink
Antiandrogens
Inhibit the binding of testosterone to the androgen receptors in the prostate
LHRH agonists
Signals pituitary to stop releasing LH, which has a direct effect on testicles & ovaries
Monoclonal Antibodies
Target specific antigens on cancer cell surface. Marks cell for attack by immune system. Blocks specific receptors. Some deliver antitumor agent to a target.
Serotonin Agonists
* Selective blockade of serotonin 5-HT3 receptors in GI tract & brain.
* HA, Diarrhea, Constipation, $$$
* Ondansetron, Granisetron, Dolasetron, Palonosetron
Phenothiazines
* Blockade of dopamine receptors in chemoreceptor trigger zone.
* Sedation, Hypotension, EPS
* Prochlorperazine, Promethazine, Triethylperazine, Trimethobenzamide
Corticosteroids
* Unknown MOA
* Insomnia, hyperglycemia, inc appetite, euphoria, aggitation/anxiety
* Dexamethasone, Methylprednisolone
Cannabinoids
* Unknown MOA
* Improves nausea, appetite, pain
Dronabinol (marinol)
Benzodiazepines
* Amnestic, anxiolytic, sedative, Great for anticipatory vomiting
* Sedation, hypotension, disinhibition, motor incoordination
* Lorazepam