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Geriatrics: Pharmacology & Elder Abuse

Terms in this set (27)

Why are older adults at greater risk for adverse drug events than younger persons?
they have characteristics that affect the body's utilization of drugs
____ alone is a bad predictor of how an older person will react to a medication
age
What are some predictors of medication response in the older adult?
- general state of health
- number and types of other medications taken
- liver and real function
- presence of comorbidities or other diagnosed disease
Impaired liver and renal function reduces what?
the ability of the body to clear out drugs
____ responses to medications may also depend on the race or ethnic background of the older person
physiological
What is pharmacogenetics?
research on how genetics affect the body's response to drugs
What is pharmacokinetics?
what the body does to the drug
What is pharmacodynamics?
what the drug does to the body
Chronic conditions of the older adults may alter ____ and _____
pharmacokinetics and pharmacodynamics
_____ are drugs that are significantly metabolized when they first flow through the liver
first pass drugs
What are some effects of decreased serum albumin levels?
- altered binding capacity
- may cause increased serum levels of unbound proportion of protein bound drugs
- may result in toxic levels of high bound drugs because more unbound drug is available to produce its effects
What are some changes in pharmacodynamics in the older person caused by?
- decreased number of receptors
- decreased receptor binding
- altered cellular response to the drug-receptor interaction
What are some reasons that older persons are more likely to have adverse drug reactions?
- inappropriate drug or dosing regimen
- drug to drug interactions
- polypharmacy
- nonadherence
____ is the prescription, administration, or use of more medications than are clinically indicated in a given patient
polypharmacy
What is iatrogenesis?
harm from a therapeutic regimen
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