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graetest alteration in hepatic aminotransferase, combination drug w/ misoprostol and with omeprazole, rectal and eye preparations, no to children and pregnant women
misoprostol (arthrotec) (PGE1--decreases GI toxicity), omeprazole (decreases GI toxicity)
diclofenac can be a combination drug with __ and __
COX2, COX1, 10/1, GI, renal
etodolac: __ inhibiton relative to __ is __; less __ toxicity, impairment of __ function
hepatic aminotransferase, children, prengnant women
diclofenac: greatest alteration in __ __; no to __
10 fold, 2, 1, no platelet, GI
meloxicam: __ __ COX__ over COX__ inhibiton, __ _ effects, less __ toxicity
alters TNF-alpha and nitric oxide synthesis, topical in eye and IV, toxicity includes rigidity, ataxia and tremor
TNF-alpha, nitric oxide synthesis, topical, IV, rigidity, ataxia, tremor
flurbiprofen alters __ and __; __ in eye and __, toxicity includeds: __, __ and __
analgesic at low doses, high doses anti-inflammatory, cream and liquid gel, less GI toxicity than aspirin, interaction w/ aspirin in anti-inflammatory and anti-platelet effects, platelet effect, aplastic anemia
analgesic, antiinflammatory, GI, aspirin, anti-inflammatory, anti-platelet, platelet, aplastic anemia
ibuprofen: __ at low doses, high doses ___, cream and liquid gel, less __ toxicity than aspirin, interaction with __ in __ and __effects, __ effect, __ __
not just because its a COX inhibitor it works, but also because TNF-alpha and Nitric oxide synthesis occurs
may decrease phopholipase A and C, decrease neutrophil migration and lymphocyte proliferation, more potent than salicylates in inflammation, some platelet effect, eye preparation, toxicity is high, GI, headache (30%) thrombocytopenia and hyperkalemia (renal toxicity)
phospholipase A and C, neutrophil, lymphocyte, potent, inflammation, platelet, eye, GI, headache, thrombocytophenia, hyperkalemia, renal
indomethacin: may decrease __, decrease __ migration and __ proliferation, more __ than salicylates in __, some __ effect, __ preparation, toxicity is high: __, __ (30%) __ and ___ (__ toxicity)
inhibits both cyclooxygenase and lipooxygenase, stabilizes lysosomes, less GI toxicity than aspirin
cyclooxygenase, lipooxygenase, lysosomes, GI
ketoprofen inhibits __ and __; stabilizes __, less __ toxicity than aspirin
prodrug, only non-acid NSAID, half life is 24 hours, less GI toxicity than aspirin, photosensitivity, and pseudoprophyria
20X more potent in COX inhibition than aspirin, long half-life, slow release available, topical and eye, greater GI bleeding than ibuprofen
20X, COX inhibition, long, greater GI, ibuprofen
naproxen: __ more potent in __ __ than aspirin, __ half-life, slow release available, topical and eye, __ __ bleeding than ___
analgesic, antipyretic, and anti-inflammatory (alters leukocyte migration, etc), long half life, highest GI toxicity at high doses
analgesic, antipyretic, antiinflammatory, long, highest GI
piroxicam: __, __, and __ (alters __ migration), __ halflife, __ __ toxicity at high doses
prodrug, metabolized to sulfide (active metabolite), reduction mediated by gut bacteria, high concentrations in colon (colorectal cance), less sulfide in upper GI and in kidney (less toxic), high liver toxicity
prodrug, sulfide, gut, colon, colorectal, sulfide, upper GI, kidney, liver
sulindac: __, metabolized to __ (active metabolite), reduction mediated by __ bacteria, high concentration in __ (__ cancer), less __ in __ and in __ (less toxic), HIGH __ toxicity
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