How can we help?

You can also find more resources in our Help Center.

70 terms

non-selective COX inhibitors

STUDY
PLAY
meloxicam
10 fold COX-2 over COX-1 inhibition, no platelet effect, less GI toxicity
diclofenac
graetest alteration in hepatic aminotransferase, combination drug w/ misoprostol and with omeprazole, rectal and eye preparations, no to children and pregnant women
diclofenac (and meclofenamate, mefanamic acid)
no to children and pregnant women
diclofenac
greatest alteration in hepatic aminotransferase
diclofenac
combination drug w/ misoprostol and with omeprazole
misoprostol (arthrotec) (PGE1--decreases GI toxicity), omeprazole (decreases GI toxicity)
diclofenac can be a combination drug with __ and __
diclofenac
rectal and eye preparations
etodolac
COX-2 inhibition relative to COX-1 is 10/1, less GI toxicity, impairment of renal function
COX2, COX1, 10/1, GI, renal
etodolac: __ inhibiton relative to __ is __; less __ toxicity, impairment of __ function
hepatic aminotransferase, children, prengnant women
diclofenac: greatest alteration in __ __; no to __
10 fold, 2, 1, no platelet, GI
meloxicam: __ __ COX__ over COX__ inhibiton, __ _ effects, less __ toxicity
flurbiprofen
alters TNF-alpha and nitric oxide synthesis, topical in eye and IV, toxicity includes rigidity, ataxia and tremor
TNF-alpha, nitric oxide synthesis, topical, IV, rigidity, ataxia, tremor
flurbiprofen alters __ and __; __ in eye and __, toxicity includeds: __, __ and __
flurbiprofen
toxicity includes rigidity, ataxia, and tremor
ibuprofen
analgesic at low doses, high doses anti-inflammatory, cream and liquid gel, less GI toxicity than aspirin, interaction w/ aspirin in anti-inflammatory and anti-platelet effects, platelet effect, aplastic anemia
Ibuprofen
has platelet effects ! (besides Aspirin)
analgesic, antiinflammatory, GI, aspirin, anti-inflammatory, anti-platelet, platelet, aplastic anemia
ibuprofen: __ at low doses, high doses ___, cream and liquid gel, less __ toxicity than aspirin, interaction with __ in __ and __effects, __ effect, __ __
ibuprofen
interaction with aspirin in antiinflammatory and antiplatelet effects
less anti-inflammatory
IBU + aspirin= ___ effect
decreased aspirin, platelets
IBU + aspirin= ___ effect on __
ibuprofen
side effect: aplastic anemia
flurbiprofen
not just because its a COX inhibitor it works, but also because TNF-alpha and Nitric oxide synthesis occurs
indomethacin
may decrease phopholipase A and C, decrease neutrophil migration and lymphocyte proliferation, more potent than salicylates in inflammation, some platelet effect, eye preparation, toxicity is high, GI, headache (30%) thrombocytopenia and hyperkalemia (renal toxicity)
indomethacin
may decrease phospholipase A and C
indomethacin
decreases neutrophil migration and lymphocyte proliferation
indomethacin
more potent than salicylates in inflammation
indomethacin
toxicity is high: GI, headache, thrombocytopenia, hyperkalemia
indomethacin
thrombocytopenia
indomethacin
hyperkalemia (renal toxicity)
phospholipase A and C, neutrophil, lymphocyte, potent, inflammation, platelet, eye, GI, headache, thrombocytophenia, hyperkalemia, renal
indomethacin: may decrease __, decrease __ migration and __ proliferation, more __ than salicylates in __, some __ effect, __ preparation, toxicity is high: __, __ (30%) __ and ___ (__ toxicity)
ketoprofen
inhibits both cyclooxygenase and lipooxygenase, stabilizes lysosomes, less GI toxicity than aspirin
cylcooxygenase and lipooxygenase
ketoprofen inhibits:
cyclooxygenase, lipooxygenase, lysosomes, GI
ketoprofen inhibits __ and __; stabilizes __, less __ toxicity than aspirin
ketorolac
potent analgesic, moderate anti-inflammatory, IM, IV used with opiods, eye
potent analgesic, anti-inflammatory, opiods
ketoralac: __ __, moderate __, IM, IV used with __, eye
ketoralac
potent analgesic
ketoralac
used w/ opiods
ketoralac
moderate anti-inflammatory
nabumetone, sulindac
prodrug
nabumetone
prodrug, only non-acid NSAID, half life is 24 hours, less GI toxicity than aspirin, photosensitivity, and pseudoprophyria
nabumetone
side effect: photosensitivity, pseudoprophyria
nabumetone
side effect: photosensitivity
nabumetone
side effect: pseudoprophyria
nabumetone
only non-acid NSAID
nabumetone
half life 24 hours
prodrug
nabumetone is a __
naproxen
20X more potent in COX inhibition than aspirin, long half-life, slow release available, topical and eye, greater GI bleeding than ibuprofen
naproxen
20 X more potent in COX inhibition than aspirin
naproxen
long half life, slow release available
naproxen
greater GI bleeding than ibuprofen
20X, COX inhibition, long, greater GI, ibuprofen
naproxen: __ more potent in __ __ than aspirin, __ half-life, slow release available, topical and eye, __ __ bleeding than ___
naproxen
NSAID with lowest risk of cardiovascular disease (other than aspirin)
cardiovascular disease
naproxen is the NSAID with the lowest risk of ___
oxaprozin
long half-life, uricosuric
oxaprozin
uricosuric (gout)
piroxicam
analgesic, antipyretic, and anti-inflammatory (alters leukocyte migration, etc), long half life, highest GI toxicity at high doses
piroxicam
alters leukocyte migration, etc
piroxicam
inhibits everything
piroxicam
highest GI toxicity at high doses
analgesic, antipyretic, antiinflammatory, long, highest GI
piroxicam: __, __, and __ (alters __ migration), __ halflife, __ __ toxicity at high doses
sulindac
prodrug, metabolized to sulfide (active metabolite), reduction mediated by gut bacteria, high concentrations in colon (colorectal cance), less sulfide in upper GI and in kidney (less toxic), high liver toxicity
sulindac
metabolized to active form sulfide
prodrug, sulfide, gut, colon, colorectal, sulfide, upper GI, kidney, liver
sulindac: __, metabolized to __ (active metabolite), reduction mediated by __ bacteria, high concentration in __ (__ cancer), less __ in __ and in __ (less toxic), HIGH __ toxicity
sulindac
HIGH LIVER TOXICITY
sulindac
prevents 2 organs from damage (GI and kidney), but very bad for liver
sulindac
sulfoxide form; reduced form is active (inhibits COX)
tolmetin
less GI toxicity than aspirin
oxaprozin
half-life of 50 hours
ketoralac
post surgey, decreases amount of opiods you need
indomethacin
more potent than aspirin as antiinflammatory