Study Group: Making Flashcards
Terms in this set (37)
Redness, swelling, heat, pain, loss of function
List the five cardinal signs of inflammation.
The Cox (1, 2) pathway is associated with "bad" prostaglandins that promote inflammation.
The Cox (1, 2) pathway is associated with the "good" prostaglandins that help regulate stomach acids, blood flow to the kidneys, and blood clotting.
Gastric ulcers, kidney toxicity, coagulopathy
List three dangerous side effects that can occur in animals taking antiinflammatories that inhibit the Cox 1 pathway.
Act on DNA and alter transcription of mRNA for certain proteins
Time needed for first NSAID to leave system before administering a second NSAID to avoid adverse effects
Firocoxib for equine
Firocoxib for dogs
(T/F) Phenylbutazone is injected into the carotid vein
Phases of wound healing
Inflammation: 0-8hrs after injury
Debridement: 6hrs-5d after injury
Repair: 3-5d after injury depending on size of wound
Maturation: 17-20d after injury; continues up to 2 years
"It Doesn't Really Matter"
Why do we want to suppress part of of the healing process?
Excessive/misdirected inflammatory response may cause pain, slow healing & cause tissue damage
May lead to organ failure & death
NSAIDs: how can it harm?
Give with food!
NSAIDs How can it harm?
Renal toxicity (is always at risk)
NSAIDs: mechanism of action?
Inhibits cyclooxygenase enzymes involved in prostaglandin synthesis
NSAIDs: How can I promote safe and effective use?
Should not be given with glucocorticoids. It block formation of inflammatory mediator
NSAIDs: How can it hurt
NSAIDs Metabolize in the liver so caution with patients that has hepatic disease or preexisting
True or False? Cats metabolize NSAIDs slowly because the lack glucuronyl tranferase
Rx - Rimadyl
Systemic Inflammatory response syndrome
Multiple Organ Dysfunction Syndrome
Drugs used to reduce or suppress inflammatory reactions in the body
They exert their effect on cells & tissues of the patient, not on an infectious agent
Methylprednisolone acetate in horses is used as
intraarticular injection for joint inflammation
long acting but therapeutic benefits may wane before physiologic effects subside
Methylprednisolone Sodium Succinate
used for critical cases requiring rapid treatment- head trauma, spinal trauma, anaphylaxis
Methylprednisolone acetate in dogs and cats is used for
dermatoses or musculoskeletal inflammation
(T/F) Diclofenac sodium comes in a topical cream that should not touch human skin
acetylsalicylic acid proprietary name
aspirin generic name
commonly used in treatment of allergic dermatitis, also for autoimmune disease (IMHA and IMT)
Flunixin meglumine uses
Anti-inflammatory and anti-pyretic, blocks effects of G(-) endotoxins, colic in horses
Diclofenac Sodium application site/frequency
Directly on the affected joint, BID
metabolized to prednisolone in the liver
Dogs can absorb hydrocortisone from
Glucocorticoids are produced in the adrenal cortex or the adrenal medulla?
(T/F) Aspirin is an approved veterinary product in the US
Short acting anti-inflammatory
Phenylbutazone used to treat
Equine osteoarthritis, laminitis, musculoskeletal pain
Inflammation of the sensitive tissues of the hoof is called _____________________