Study Group: Making Flashcards

Terms in this set (37)

Redness, swelling, heat, pain, loss of function

List the five cardinal signs of inflammation.

The Cox (1, 2) pathway is associated with "bad" prostaglandins that promote inflammation.

The Cox (1, 2) pathway is associated with the "good" prostaglandins that help regulate stomach acids, blood flow to the kidneys, and blood clotting.

Gastric ulcers, kidney toxicity, coagulopathy

List three dangerous side effects that can occur in animals taking antiinflammatories that inhibit the Cox 1 pathway.

Glucocorticoids

Act on DNA and alter transcription of mRNA for certain proteins

Time needed for first NSAID to leave system before administering a second NSAID to avoid adverse effects

Firocoxib for equine

Firocoxib for dogs

(T/F) Phenylbutazone is injected into the carotid vein

Phases of wound healing

Inflammation: 0-8hrs after injury
Debridement: 6hrs-5d after injury
Repair: 3-5d after injury depending on size of wound
Maturation: 17-20d after injury; continues up to 2 years

IDRM
"It Doesn't Really Matter"

Why do we want to suppress part of of the healing process?

Excessive/misdirected inflammatory response may cause pain, slow healing & cause tissue damage
May lead to organ failure & death

NSAIDs: how can it harm?

GI ulceration
Give with food!

NSAIDs How can it harm?

Renal toxicity (is always at risk)

NSAIDs: mechanism of action?

Inhibits cyclooxygenase enzymes involved in prostaglandin synthesis

NSAIDs: How can I promote safe and effective use?

Should not be given with glucocorticoids. It block formation of inflammatory mediator

NSAIDs: How can it hurt

NSAIDs Metabolize in the liver so caution with patients that has hepatic disease or preexisting

True or False? Cats metabolize NSAIDs slowly because the lack glucuronyl tranferase

Systemic Inflammatory response syndrome

Multiple Organ Dysfunction Syndrome

Anti-inflammatories

Drugs used to reduce or suppress inflammatory reactions in the body

They exert their effect on cells & tissues of the patient, not on an infectious agent

Methylprednisolone acetate in horses is used as

intraarticular injection for joint inflammation

Methyprednisolone acetate

long acting but therapeutic benefits may wane before physiologic effects subside

Methylprednisolone Sodium Succinate

used for critical cases requiring rapid treatment- head trauma, spinal trauma, anaphylaxis

Methylprednisolone acetate in dogs and cats is used for

dermatoses or musculoskeletal inflammation

(T/F) Diclofenac sodium comes in a topical cream that should not touch human skin

acetylsalicylic acid proprietary name

aspirin generic name

Prednisolone/ Prednisone

commonly used in treatment of allergic dermatitis, also for autoimmune disease (IMHA and IMT)

Flunixin meglumine uses

Anti-inflammatory and anti-pyretic, blocks effects of G(-) endotoxins, colic in horses

Diclofenac Sodium application site/frequency

Directly on the affected joint, BID

metabolized to prednisolone in the liver

Dogs can absorb hydrocortisone from
___________ application

Glucocorticoids are produced in the adrenal cortex or the adrenal medulla?

(T/F) Aspirin is an approved veterinary product in the US

Short acting anti-inflammatory

Phenylbutazone used to treat

Equine osteoarthritis, laminitis, musculoskeletal pain

Inflammation of the sensitive tissues of the hoof is called _____________________

;