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Chapter 16-Drugs treating Mood Disorders
Terms in this set (15)
Major Depressive Disorder Symptoms
Within a 2-week period a person must manifest a depressed even tearful mood. As well as a diminshed interst or lack of pleasure in all activities most of the day.
Changes in appetite, weight, sleep or energy; decrease in concentration; recurring death wishes; or thoughts of suicide
Risk factors for depression
Having previously been depressed
Having a first-degree relative diagnosed with depression
Being a woman, an adolescent, or a young adult
People with this disorder often see themselves as incapable, and their thoughts are filled with self-criticism and excessive guilt
This is a brain disorder that not only causes unusual shifts between low and elevated mood but affects energy, activity levels, sleep, thought process, and judgment in extreme ways.
What is the optimal therapeutic effect for most antidepressants?
10 days to 4 weeks
What is the goal of antidepressant therapy?
To bring about the greatest relief of symptoms while minimizing ay unpleasant adverse effects.
What is the first drug of choice in treating depression?
Why are SSRIs the first drug of choice in treating depression?
They can be less damaging to the heart and have minimal anticholinergic and hypotensive effects
What are some common SSRIs?
What is currently the most widely prescribed SSRI?
Used to treat depression, OCD, panic disorder and PTSD
Major contraindications: Cautious use in patients with decreased liver function
Most common adverse effects: GI distress, headache, sleep distrubance, and abnormal ejaculation
Maximizing therapeutic effect: Encourage patient to continue medicine, even though the immediate response does not occur and continue medication well after an improvement is experienced.
Most important patient education: teach that a lag time occurs between beginning therapy and relief of symptoms; avoid alcohol and drugs
May increase the risk of sucidal thoughts or behaviors in children, adolescents, and young adults
A weak blocker of neuronal uptake of norepinephrine and serotonin. It also inhibits reuptake of dopamine. Usual dose is 300 mg/d
Mixed norepinephrine and serotonin reuptake inhibitor.
May cause constipation, diaphoresis, dizziness, hypertension, nausea, nervousness, somnolence, and distrubance in sexual function.
Have a three-ring nucleus
Generally categorized as secondary or tertiary amine. Tertiary amines have a very narrow therapeutic index.
Enhance the activity of norepinephrine and serotonin by blocking neuronal reuptake of these neurotransmitters
Has a narrow therapeutic index. Considered the drug of choice for bipolar disorder
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