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Bleeding Disorders Overview

Terms in this set (11)

what conditions do bleeding disorders include (4)
vascular defects (easy bruising)
platelet disorders (low or abnormal function)
coagulation disorders (factor deficiency)
mixed (DIC)
what are the bleeding disorders cause superficial bleeds into skin and mucous membranes (2)
vascular defects
platelet disordes
what disorders cause immediate prolonged bleed after injury (2)
vascular defects
plt disorders
what disorders cause deep tissue bleed (muscle, joints) (1)
coagulation disorders
what disorders cause delayed, severe bleed after injury (1)
coaguation disorders
what are some congenital vascular defects (2)
Connective tissue disease
osler-weber-rendu syndrome
what are some acquired vascular defects 4)
senile purpura, infection (meningococcal, measles, dengue), steroids, scurvy (perifollicular haemorrhages)
what are acquired (3) and congenital (2) causes of decreased plt function
acquired
- aspirin
- cardiopulmonary bypass
- uraemia
congenital
- storage pool disease
- thrombasthenia (glycoprotein deficiency)
what are the 2 pathophysiological causes of thombocytopenia, and what are some examples of these (1, 2)
decreased production
- bone marrow failure
increased destruction
- auto-immune thrombocytopenic purpura
- drugs (heparin, DIC, HUS, TTP)
features of acute vs chronic AITP (peak age, F:M, preceding infection?, onset of symptoms, plt count and presentation, duration, spontaneous remission?)
acute
- 2-6 year olds
- 1:1
- common preceding infection
- abrupt onset
- <20,000 plts
- 2-6/52 duration
- common spont. remission
chronic:
- adults
- 3:1
- rare preceding infection
- abrupt indolent onset
- <50,000 plts
- long-term disease (associated with autoimmune diseases, CLL, HIV)
- uncommon to spont remission
treatment of chronic AITP (3)
IVIg, steroids, splenectomy
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