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Terms in this set (59)
What are the names for insulin in C. Elegans and Drosophilia
C-elegan- INS 1-38
What is a PTK
Protein tyrosine Kinase
What is a RTK. how does it work on insulin
Receptor tyrosine kinase
Insulin acts on it, IRS is a substrate for insulin receptor which is a receptor tyrosine kinase .
What part of the pathway is conserved early?
Insulin itself is a conserved pathway.
How is insulin made?
Preprohormone- Signal BCA
What is the IR for Drosophila?
C. Elegan- DAF-2
What are DILP? What are they similar to?
Dropsophilia Insulin like peptide.(insulin)
Similar to insulin preprohormone because signal-BCA structure.
Which insulin receptors are RTK's
What are the two parts of the RTK?
Subunit A which is all outside membrane
Subunit B which is 1/3rd outside membrane
What are the three RTK domains? Which is the hallmark and what does it do?
Kinase Domain- begins phosphorylation of both sides/hallmark
C-terminal Domain- ends the sequence
What are the three domains for the IRS?
How many IRS are there?
What is Drosphilia IRS?
What happens when you knock out IRS-1?
1- growth retardation/insulin resistance. IRS-2 compensates
2-Insulin resistance, but growth defects only to pancreas. This causes type 2 diabetes
What and where does CHICO bind to? What domains does it have?
It binds to DINR. It is the IRS for Drosophilia. It has a C-terminal region and PH/PTB domains/n-terminal domain.
What is PI3k for Drosophilia/C. Elegan
C. Elegan- Age-1 PI3K
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