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60 terms

Anemia

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stem cell growth factors
scf (c-kit ligand), flt3-ligand
granulocyte growth factor
gm-csf
eosinophil growth factor
il-5
monocyte growth factor
m-csf
rbc growth factor
epo
megakaryocyte/platelet growth factor
thrombopoietin
b cell growth factor
flt3-ligand
t cell growth factor
il-7
nk growth factor
il-15
heinz bodies
denatured hemoglobin
macrocytic target cells
liver disease
microcytic target cells
thalassemia
irregular spikes on rbc
acanthocytes
burr cell rbc
echinocyte
Cells in B12/folate deficiency
hypersegmented neutros
Major problem in B12 deficiency
neurological
Most common cause of pernicious anemia
antibodies to parietal cells
Anemia with atrophic glossitis and SACD
pernicious
Place of absorption for B12
terminal ileum
place of absorption for folate
jejunum
place of iron uptake
duodenum
iron deficiency is ___, including cancer, until proven otherwise
gi blood lose
microcytic hypochromic anemia, atrophic glossitis, esophageal webs
plummer-vinson syndrome
koilonychia (spoon nails)
anemia
key lab finding in Fe deficient anemia
increased tibc
mechanism for beta thalassemia
gene mutation
mechanism for alpha thalassemia
gene deletion
marker in beta thalassemia major
increased hbf
marker in beta thalassemia minor
increased hba2
form of alpha thalassemia that is most likely to be passed on is most prevalent in...
asia
Lose of 3 genes in alpha thalassemia
HbH disease
Loss of 4 genes in alpha thalassemia
Hb barts
type of cells seen in thalassemia
microcytic target cells
inherited aplastic anemia
fanconi anemia
TAR babies
fanconi anemia
hereditary pattern of hereditary spherocytosis
autosomal dominant
two possible deficiencies in hereditary spherocytosis
ankyrin, spectrin
PNH gene defect
piga
gene production deficient in pnh
gpi
Triad for pnh
hemolysis, pancytopenia, thrombosis
inheritance in g6pd
x-linked
cells in g6pd defect
bite cells, heinz bodies
defect in sickle cell anemia
beta chain, 6, glutamate replaced by valine
defect in SC disease
beta chain, 6, glutamate replaced by lysine
hemoglobin that is protective in sickle cell
hbf
dactylitis
sickle cell in kids
cells in warm autoimmune hemolytic anemia
spherocytes, reticulocytosis
most common Ig in warm autoimmune hemolytic ame,oa
IgG kappa
most common Ig in cold agglutinins
Igm
antigen in mycoplasma pneumonia cold agglutinins
anti-I
antigen in ebv cold agglutinins
anti-i
antigen in cold hemoysins
anti-p
microangiopathic hemolytic anemias
dic, hus, ttp
hus triad
schistocytes, thrombocytopenia, renal failure
ttp pentad
schistocytes, thrombocytopenia, renal failure, neuro signs, fever
most common cause of ttp
antibodies to vwf
increased protein in porphyria with neuro symptoms
amlev
screening for acute attacks of porphyria
urine pbg
most common porphyria
porphyria cutanea tarda
mutation in polycythemia rubra vera
jak2