Neurotransmitter Receptors

GABA A
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Terms in this set (14)
GABA A
ionotrophic receptor, ligand-gated ion channel, conducts Cl- through its pore, 5 subunits
GABA B
metabotropic receptors, linked via G proteins to potassium channels (hyper polarizes the cell), inhibitory receptors, reduces activity of adenylyl cyclase and Ca2+ channels by using G proteins with Gi/Go subunits
AMPA
Fast
lower affinity for glutamate
quickly depolarizes the cell
Entry of Na+ (some Ca+)
NMDA
slower
higher affinity for glutamate
Entry of Ca+ (some Na+)
Kainate
Not as common
Entry of Ca+ and Na+
mGluR1
metabotropic receptor, post-synaptic, increase NMDA receptor activity and risk of exotocity
mGluRI/II
metabotropic receptor, pre and post-synaptic, decrease NMDA receptor activity
5 HT1A
Gi, G coupled serotonin receptor, decreasing cellular levels of cAMP, inhibitory, agonist: Buspirone
5 HT-2A,2B
Gq, G coupled serotonin receptor, increasing cellular levels of IP3 and DAG, excitatory, agonist: LSD, DMT, antagonist: antipsychotics
5HT-3
ligand gated Na+ and K+ cation channels, depolarizing plasma membrane, excitatory, antagonist: odanestron
5HT-4,6,7Gs, G coupled serotonin receptors, increasing cellular levels of cAMP, excitatory5HT-5G coupled serotonin receptors, increasing cellular levels of cAMP, inhibitoryDA1-like receptorD1, D5, G coupled receptors that are coupled to Gs (excitatory), not many clinically used drugs work on DA1-like receptorsDA2-like receptorD2, D3, D4: G coupled receptors that are coupled to Gi/Go (inhibitory), agonist: bromocriptine, antagonists: haloperidol