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ID_TB, Flu, anti-virals
Terms in this set (64)
What has the greatest mortality rate of all vaccine preventable illnesses?
Which strains of flu have antigenic drift?
A and B
Which strains of flu have antigenic shift?
When is there no benefit in treating previously healthy adults and kids for the flu?
If treatment started 2 days after onset
What are the flu medications available?
Adamantanes and Neuraminidase inhibitors
Which strains of flu do neuraminidase inhibitors treat?
A and B
Which drugs are considered neuraminidase inhibitors?
Oseltamivir and Zanmivir
What is the MOA of neuraminidase inhibitors?
Blocks viral aggregation and release
What class of drugs end in -mivir?
What drugs are in the class adamantane derivatives?
What strains of flu to adamantane derivatives treat?
What is the MOA of adamantane derivatives?
Interfere with influenza A M2 protein
Which influenza treatment class is associated with rapid development of resistance?
Which drug class causes CNS issues such as difficulty concentrating, insomnia, nervousness?
Which drugs can cause neuropsychiatric side effects?
Oseltamivir and Zanamivir
What is the treatment duration for influenza?
What is the primary drug for treatment of TB?
What is the MOA of Isoniazid?
inhibits production of mycolic acid
What are the adverse effects of isoniazid?
peripheral neuropathy and hepatotoxicity
Which drug do you need to increase monitoring when patient also on phenytoin, carbamazepine or warfarin?
What drug is the most potent sterilizing agent?
What is the MOA of rifampin?
RNA polymerase inhibition
What is an adverse effect of rifampin?
Orange body fluid discoloration
Which drug has many notable drug interactions, such as warfarin and anticonvulsants?
What drug is used as a substitute for rifampin due to drug interactions?
What drugs MOA for TB is not completely understood?
What drug is the least effect of the first line drugs against TB?
What is an adverse effect of ethambutol?
What drug classes are used for HIV treatment?
What drugs are used for HSV/VSV treatment?
What drugs are anti-CMV agents?
What HIV drug class ends in -dine?
How are nucleoside HIV drugs usually administered?
What is the MOA of nucleosides?
Competitive inhibitors of HIV-I reverse transcriptase
What are all NRTIs associated with as an adverse effect?
Who is at the greatest risk of a hypersensitivity reaction with abacavir?
patients that test positive for HLA-B*5701 genotype
Which HIV drug causes hyperpigmentation and skin discoloration?
Which HIV drug causes Fanconi syndrome?
Which HIV drug causes bone marrow suppression and lipotrophy?
What is the MOA of NNRTIs?
Bind to HIV-1 reverse transcriptase inhibiting polymerase activity
(do not require activation)
Which NNRTI causes neuropsychiatric symptoms?
Which HIV drug class ends in -navir?
What is the MOA of protease inhibitors?
prevent processing of viral proteins
(do not need activation)
Which HIV drug class can cause a cushingoid appearance?
Which HIV drug class can cause QT prolongation?
What HIV drugs are in the class fusion/entry inhibitors?
What is the MOA of HIV drug enfuvirtide?
Block HIV entry into cell through GP4I subunit
What is the MOA of HIV drug maraviroc?
Blocks host protein CCR5 inhibiting HIV cell entry
Which HIV drug has limited use due to availability only as a subcutaneous injection?
Which HIV drug is the only agent that uses the CCR5 co-receptor exclusively?
Which HIV drug requires testing prior to starting therapy due to the exclusivity of the MOA?
Which HIV drug class ends in -gravir?
What is the MOA of integrase inhibitors?
Inhibits strand transfer and integration
Which HIV drug can cause life-threatening liver injury?
Which HIV drug must be boosted by cobiscistat?
Which drug class ends in -clovir?
What is the treatment of choice for herpes simplex, encephalitis, neonatal HSV and serious HSV/VSV?
Which HSV drug is associated with reversible renal toxicity?
Which HSV/VSV drug causes hallucinations?
Which agents have activity against CMV?
Which CMV agent causes myelosuppression?
WHich CMV agent causes proximal tubular nephrotoxicity and ocular hypotony?
What can help prevent nephrotoxicity with Foscarnet use in CMV patients?
Normal saline preloading
What CMV drug can cause calcemia and phosphate disturbances as well as hypomagnesmia?
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