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2050 Ch. 6 Adrenergic (sympathomimetic) bronchodilators
Terms in this set (33)
agent that stimulates sympathetic nervous fibers, which allow relaxation of smooth muscle n the airway. also known as sympathomimetic bronchodilator or B2 agonist
causes vasoconstriction and vasopressor effect; in the upper airway (nasal passages),, this can provide decongestion
refers to the increasing incidence of asthma morbidity, and especially asthma mortality
B1 receptor Stimulation
causes increased myocardial activity and increased heart rate as well as contractile force
B2 receptor stimulation
causes relaxation of bronchial smooth muscle, with some inhibition of inflammatory mediator release and stimulation of mucociliary clearance
narrowing of the bronchial airways caused by contraction of smooth muscle
group of similar compounds having sympathomimetic actions; they mimic the actions of epinephrine
causes relaxation of bronchial smooth muscle
long-term desensitization of beta receptors to beta 2 agonist, caused by a reduction in the number of beta receptors
drug that exhibits its pharmacologic activity when it is converted, inside the body, to its active form
producing effects similar to those of sympathetic nervous system
Keyhole theory of beta sympathomimetic receptors
the larger the side chain attachment to a catechol base, the greater the beta 2 specificity
An enzyme that produces a reaction the opposite of that cyclic adenosine monophosphate (cAMP), and causes bronchoconstriction
Narrowing of the airways resulting from contraction of smooth muscle is called
A group of similar compounds having sympathomimetic action and mimicking the actions of epinephrine is the
An agent that stimulates sympathetic nervous fibers and allows relaxation of smooth muscle in the airway is
A drug that exhibits pharmacologic activity once it is converted, inside the body, to its active form is
A- receptor stimulation
causes vasoconstriction and a vasopressor efect in the upper airway, which provides decongestion
B1 receptor stimulation
causes increased myocardial conductivity and increased heart rate, as well as increases contractile force
Long term desensitization of B receptors to B2 agonists, caused by a reduction in the number of B receptors is
is a nucleotide produced B2 receptor stimulation that causes relaxation of bronchial smooth muscle
Cyclic amp cAMP
What is the general indication for adrenergic bronchodilators?
relaxation of airway smooth muscle to reverse or lessen the degree of airflow obstruction
Epinephrine can be administered by ____and ____ to treat patients with asthma exacerbation
Inhalation and subcutaneously
Why can't catecholamines be given orally?
They are inactivated in the gut and liver
three ways albuterol could be delivered
mouth, MDI, Aerosol, Syrup
A noncatecholamine adrenergic drug. available only for metered dose inhaler (MDI) administration with a breath actuated inhaler delivery device
T or F Bitolterol is a prodrug
T or F Levalbuterol (Xopenex) is the (R)-isomer of Albuterol
T or F Arformoterol is available as a small volume nebulizer (SVN)
What group of drugs must be given by inhalation because they are ineffective orally?
Adverse side effects with B agonists
tremors, headaches, insomnia, bronchospasm, palpilations
Metaproterenol is an example of which type of adrenergic bronchodilators?
Sets found in the same folder
Egan's Chapter 33 Airway Management
Rau's Respiratory Pharmacology: Chapter 5
CH 6 Adrenergic (Sympathomimetic) Bronchodilators
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