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synaptic knob or terminal
at end of axon, contains synaptic vesicles which store and release neurotransmitters
synapse, synaptic cleft
junction between to nerve cells or between nerve cells and glands or muscle cells
types of synapses
electrical - cell to cell contact via gap junctions (heart)
chemical- NT's from presynaptic cell pass across synapse (most)
information is transmitted
electrically down presynapttic cell, chemically across synapse, electrically down post synaptic cell
difference in charge or voltage between 2 sides of a membrane, potential energy used to run nerve impulse
cause of difference in electric charge across membrane
1. Na/K pump - membrane not very permeable to these ions
2. cell membrane is slightly more permeable to K so some diffuses out down its gradient, making it more negative inside
3. negatively-charged ions in the cytosol
local change in charge across the membrane due to Na and K gates closing in succession in just one area of the membrane
1. Na gates open
2. Reversal of charge
3. Na gates close
4. K gates open
5. back to resting potential
lasts approx. one millisecond
sections of a neuron during a nerve impulse
1. polarized/resting (Na + K gates closed) -70
2. Action Potential/Depolarized (Na open K closed) -70:+35
3. Repolarized (Na closed K open) +35:-90
4. polarized/resting (Na + K gates closed) -90:-70
if the stimulus is strong enough to cause the cell to change from -70 mV to -50 mV - causes the charge of the cell to completely reverse, and the inside becomes + 35 mV
(if not strong enough, membrane can still become partially depolarized)
-50 causes Na voltage-sensitve gates to open which makes it go from -50 to +35 as more Na+ diffuses into cell
causes of depolarization
1. stimulus (binding of NT) causes Na ligand-sensitive gates there to open, and pressure will cause mechanical-sensitive gates to open. Cell becomes permeable to Na (-70:-50)
2. If threshold is reached, initial partial depolarization will lead to complete depolarization = reversal of charge across membrane (+35).
3. Action potential is all-or-none event
4. an action potential is always the same strength +35 regardless of strength of a stimulus - stronger stimulus just makes more action potentials
cell membrane becomes impermeable to Na as Na gates close behind action potential. membrane becomes more permeable to K as K gates open. K moves out of cell and original polarized state is reestablished. Na/K pump then restores resting cell condition where high Na outside and high K inside by pumping.
review of action potential
A resting cell is in a polarized state.
It can become depolarized due to a stimulus, and may reach threshold potential.
This causes an action potential.
This is followed by depolarization.
Then another action potential may be sent.
when Na gates close after action potential, they cannot be reactivated for a brief time, to prevent the Na that entered during depolarization from re-exciting the region behind the action potential. This insures that the impulse can only travel in one direction: from the body to the axon knobs.
some NTs cause a membrane potential to become greater than resting potential (cell goes from -70 to -90); more negative not he inside. This reduces the chances of an action potential being initiated because -90 is further from the threshold level.
Due to a particular type of NT that binds to K gates instead of Na gates - when the K gates open, K diffuses out of the cell making the interior more negative than resting potential.
a local voltage change proportional to the strength of the stimulus. type of change in membrane potential that is a single stimulus and usually not enough to bring the membrane to threshold level, therefore an action potential does not generate.
Most EPSPs and IPSPs at the synapse are graded potentials. Alone neither will initiate or inhibit a nerve impulse.
excitatory post synaptic potential
If after binding NTs, the membrane becomes depolarized, an EPSP is generated.
Excited = brought closer to threshold level (-70 mV to anything less negative)
Inhibitory Post Synaptic Potential
If after binding NTs, the membrane becomes hyper polarized, an IPSP is generated.
Inhibited = brought farther away from threshold level (-70 to anything more negative)
a process at the synapse where EPSPs and IPSPs are integrated
all of the stimulus received by a post-synaptic cell "added together", and when the additive effect of these graded potentials reaches the axon hillock of the neuron an action potential may or may not be initiated.
Can be temporal or spatial
EPSPs and IPSPs
lose strength the farther they travel away from the initial stimulus = the voltage changes from all the EPSPs and IPSPs will diminish as they reach the axon hillock
not considered APs because not at axon hillock
repeated sub-threshold stimuli from the same neuron that occur in quick succession
takes many synaptic knobs from different neurons releasing NTs simultaneously not eh same post-synaptic membrane to reach threshold
rate of transmission
1. the larger the diameter of the axon, the faster the transmission (less resistance to flow of electric current)
2. saltatory conduction - impulse jumps from node to node - Na and K channels are concentrated at the nodes and action potentials can only be generated in these areas. In a non-myelinated neuron, Na and K gates exist all the way down the length of the axon so there are many more action potentials generated. this increases transmission rate because there are far fewer action potentials that have to be generated before the axon knob is stimulated to release NTs
occurs in myelinated neurons (areas with myelin- high in lipid content) are poor conductors of electrical impulses
Transmission across synapse
when action potential reaches the synaptic knob, it causes Ca++ channels to open, which diffuses into axon job and causes synaptic vesicles to fuse with presynaptic membrane, and NTs are released into synapse.
NTs bind to receptors on postsynaptic membrane, Na+ Gates open, Na difffuses into cell = causes graded potential in postsynaptic cell
NTs remain only briefly in synapse so there is not a constant stimulation to post-synaptic nerve.
After transmission, NTs are
1. returned to presynaptic knob
2. degraded by enzymes from presynaptic cell(acetylcholinesterase degrades acetylcholine at synapse)
cells that cause an effect or elicit a response
can be glands (secrete hormones) or muscles (contract)
connects sensory and motor neurons
Located within CNS
most neurons are interneurons (90%) in the brain or spinal cord
1. specialized nerve cells (rods and cones of eye)
2. dendrites of a sensory neuron
any factor that induces a change in environment and evokes a response
ex. light, pressure, sound
stimulus - sensory receptor - sensory neuron - interneuron - motor neuron - effector - response
supporting cells- help assist, protect, insulate, and reinforce neurons
most nerve cells are glial cells, not neurons
don't transmit messages
provide support for neurons and other jobs
during development these cells induce the formation of tight junctions between capillary endothelial cells, forming the blood-brain barrier
a barrier that helps prevent harmful substances from entering the brain and spinal cord from the circulatory system
schwann cells and oligodendocytes
wrap around some axons in many concentric layers like a jelly roll
form myelin sheaths that insulate axon
lots of phospholipids in membrane
cause poor conduction of electrical impulses
causes impuse to jump from node to node = increase rate of nerve impulse
made of amino acids
epinephrine (adrenaline), norepinephrine (noradrenaline), dopamine, serotonin
too much or to little of these cause illness (parkinson's, schizo, sleep disorders, depression, etc)
drugs can interfere with this chemical communication
how drugs affect catecholamines
1. drugs bind to receptors for NTs and block impulse
2. drugs mimic NTs and induce impulse (LSD and barbiturates- bind receptors and alter brain activity)
present at most inhibitory sun apses - hyper polarizes the membrane to inhibit action potentials; most abundant NT in brain
neural analgesic (pain reliever)
1. decreases pain
2. elevates mood (opium binds same receptors and has similar but stronger effect)
2. Catecholamines - AAs (epinephrine/adrenaline, norepinephrine/noradrenaline, dopamine, seratonin)
3. Pepties/neuropetides - AAs (GABA, Endorphines)
4. Gases (NO)
Energy needed to run a nerve impulse
ATP - indirectly - Na/K pump to establish a gradient
ATP - directly - to run Na/K pump
Potential E (ATP) --> Pot E (Gradient) --> gradient used to do work
many times cell uses proton gradients as pot E
requires a proton gradient to produce ATP
Active transport directly to help protein change configuration Na or H+ gradients as an energy source
Facilitated diffusion - many molecules bumping into channel is enough to change configuration of protein
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