Case 57: Immune Thrombocytopenic Purpura
Terms in this set (16)
if a healthy 3 year old develops thrombocytopenia, petechiae, and purpura, what is the most likely diagnosis?
What should happen to the hemoglobin level and WBC count in a patient with ITP?
They should remain normal
What are the characteristics of hemolytic-uremic syndrome?
Nephropathy, thrombocytopenia, and microangiopathic hemolytic anemia
What organisms are typically responsible for HUS?
EHEC O157H7, salmonella, and shigella
What symptom commonly accompanies HUS?
What is the classic triad of Henoch-Schonlein purpura?
Abdominal pain, palpable purpura on the lower extremeties, and nephritis
What type of vasculitis is Henoch-Schonlein purpura?
A small vessel vasculitis
What is ITP?
A condition of increased platelet destruction by circulating antiplatelet antibodies
What is the most common cause of thrombocytopenia in a well child between the ages of 2 and 10?
If significant organomegaly or lymphadenopathy is present, is the diagnosis likely to be ITP?
No it is not
What can be seen on the peripheral blood smear in cases of ITP?
Eosinophilia and atypical lymphocytes
What is the most serious complication of ITP?
Intracranial hemorrage. This occurs is less than 1 percent of affected children
What are possible treatments to decrease platelet destruction in ITP?
IV immunoglobulins, IV anti-D therapy, and corticosteroids
What additional therapy can be done for patiens with severe complications who are not responding to other therapies?
After splenectomy what vaccines are very important to give?
Vaccines directed against encapsulated organisms, such as the pneumococcal and meningococcal vaccines
Is it possible for pharmacologic agents to cause immune mediated destruction of platlets?
Yes it is
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