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Pharmaceutics Exam 3
Terms in this set (34)
The diffusion coefficient, D, of the drug in the GI fluids may be _____ by the presence of food.
An increase in gastric and/or intestinal motility may _____ the dissolution rate of a sparingly soluble drug.
Will a large volume of fluid increase or decrease dissolution rate?
Small particle size leads to _____ surface area.
Solubility of weak acids is:
a. higher in stomach than in small intestine
b. higher in small intestine than in stomach
c. there is no rule of thumb regarding anatomic location where solubility is greater
higher in small intestine than in stomach
Which drug is more appropriate to treat a toothache?
b. naproxen sodium
c. naproxen and naproxen sodium are equally appropriate
Which will have a faster dissolution rate?
b. chlorpromazine HCl
Cyclodextrin complexes are:
When a drug is unstable in gastric fluid, to minimize its degredation in gastric fluid, you should _____ its dissolution in gastric fluid.
Choose the correct statement:
a. Most drugs are weak electrolytes.
b. Most drugs are strong electrolytes.
c. The number of drugs that are weak electrolytes is approximately similar to the number of drugs that are strong electrolytes.
most drugs are weak electrolytes
Which form of drugs that are weak acids or bases will better penetrate through the GI epithelium?
a. ionized form
b. unionized form
c. ionization does not affect penetration through the GI epithelium
Drugs that are poorly lipid soluble (=polar) (log P < 0) AND have a small MW will be absorbed (eg., atenolol) how?
a. paracellular diffusion
b. transcellular passive diffusion
c. transcellular active transport
d. transcellular facilitated diffusion
For low MW materials, which solidification process does not enable the molecules to align in the correct way to form a crystal?
a. very slow
b. very fast
The majority of drugs and excipients are
a. crystalline solids
b. amorphous solids
c. semi-crystalline solids
Which crystal for would usually have faster dissolution rate?
a. crystalline form
b. amorphous form
c. there is no connection between crystal form and dissolution rate
Which statement is true?
a. amorphous drugs are always better absorbed than crystalline drugs
b. amorphous drugs may be better absorbed than crystalline drugs, when absorption is dissolution rate limited
c. there is no connection between bioavailability and crystal state
amorphous drugs may be better absorbed than crystalline drugs, when absorption is dissolution rate limited
High solubility and dissolution rate can usually be obtained for which polymorph?
Can some drugs exist in more than one hydrate form?
For hydrates and dissolution rate,
a. water acts as a wedge (less common)
b. water forms hydrogen bonds (more common)
c. none of the above
water acts as a wedge (less common)
T/F: The larger the mesh size, the smaller the sieve openings and the smaller the particles must be to pass through that sieve.
a. always true
b. always false
c. true only for high sieve number
d. true only for low sieve number
For mixing without comminution, the preferred mortar and pestle are usually made of
c. there is no connection between the need for comminution and the material from which the mortar and pestle are made of
T/F: It is acceptable to sift potent drugs for incorporation into diluent powder.
Particles of a suitable shape will flow better if they are within which of the following size ranges?
a. < 100 µm (very fine)
b. 250 - 2000 µm (coarse to fine)
250 - 2000 µm (coarse to fine)
Particles with which shape flow better?
b. needle shaped
T/F: Granules usually have a greater surface area than powders.
How can excessive compaction pressure affect dissolution rate?
a. increase dissolution rate
b. decrease dissolution rate
c. compaction pressure does not affect dissolution rate
decrease dissolution rate
Which statement is true?
a. Most drugs are more stable in liquid dosage forms.
b. Most drugs are more stable in solid dosage forms.
c. There is no connection between drug stability and the dosage form
most drugs are more stable in solid dosage forms
Hard or soft gelatin capsules: one has two pieces - a longer body and a shorter cap; the other has only one piece. Which is which?
a. hard = 2 pieces; soft = 1 piece
b. hard = 1 piece; soft = 2 pieces
hard = 2 pieces; soft = 1 piece
T/F: Soft gelatin capsules are suitable as vehicles for aqueous liquids.
Shells of soft gelatin capsules are _____ than that of hard gelatin capsules.
T/F: An excipient may sometimes have different roles in various tablet formulations.
If the dose of the drug per tablet is high, is there a need for a diluent?
A binder is more effective when it is added to a powder as a
a. dry powder
T/F: Formulative factors other than the presence of disintegrants can affect the disintegration time of compressed tablets significantly.
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