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Psychiatry
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Terms in this set (137)
Haloperidol
First generation
Chlorpromazine
First generation
Perphenazine
First generation
Fluphenazine
First generation
Risperidone
Second generation
Paliperidone
Second generation
Quetiapine
Second generation
Aripripazole
Second generation
Olanzapine
Second generation
Ziprasidone
Second generation
Clozapine
Second generation
Risperidone SE
Hyperprolactinemia (amenorrhea, galactorrhea, gynecomastia)
Ziprasidone SE
QT prolongation
(less wt gain than other 2nd gen)
Olanzapine and quetiapine SE
Weight gain, diabetes, sedating
Aripiprazole SE
Weight neutral
First generation SE
Tremors, tardive dyskinesia, dystonia
Second generation SE
Weight gain, hyperlipidemia, hyperglycemia (risk DM), increased appetite
Tx dystonia
Benztropine, diphenhydramine
Tx tardive dyskinesia
Clozapine
Tx akathisia
Propranolol
Clozapine SE
1. Agranulocytosis
2. Myocarditis
3. Metabolic effects
Vanderbilts ADHD criteria
6-9 in either inattentive or hyperactive sx category, sx need to be present in >1 setting
1st line treatment ADHD
Methylphenidate
2nd line treatment ADHD
Amphetamine
Methylphenidate medications
Ritalin, concerta
Amphetamine medications
Adderall, vyvanse
3rd line treatment ADHD
Atomoxetine
Alpha-agonists (clonidine)
Bupropion
SSRI with longest half life
Fluoxetine
SSRI with shortest half life
Fluvoxamine
SSRI with highest rate QTc prolongation
Citalopram
SSRI often associated with discontinuation syndrome
Paroxetine
Length of time for adequate SSRI trial
6-8 weeks at dose
Mood disorders (4)
1. MDD
2. Bipolar
3. Cyclothymia
4. Dysthymia
Psychotic disorders (4)
1. Brief psychotic episode
2. Schizophreniform
3. Schizophrenia
4. Delusional disorder
Length of time for brief psychotic episode
<1 month
Length of time for delusional disorder
>2 months
Length of time for acute stress disorder
<1 month
Length of time for schizophreniform disorder
1-6 months
Length of time for mania
at least 1 week
or hospitalization
Length of time for hypomania
at least 4 days
Mixed mood/psychotic disorder (1)
Schizoaffective
Psychotic features greater/= 2 weeks without mood disturbance
Features overlap ~50% of time
Mood disorder with psychotic features (2)
1. MDD with psychotic features
2. Bipolar disorder with psychotic features
Labs for patient on lithium
"q6 months: TSH, q1 year: BUN, T3RU"
Clozapine ADR
Leukopenia
Lithium toxicity treatment
"mild (< 3): IV fluids, monitor urine and lithium levels, evere: emergency dialysis"
Labs for patient on carbamazepine
"1st 2 months: SGOT/SGPT/LDP monthly, q3 months: SGOT/SGPT/LDP"
Valproic acid pregnancy category
X
Lithium pregnancy category
D
Carbamazepine ADR
Aplastic anemia, Stevens Johnson
Treatment of tardive dyskinesia
"1. Lower or stop antipsych dose, 2. Clozapine"
Preferred treatment for psychotic sx in Parkinson patient
Clozapine
Drugs that increase carbamazepine levels
Erythromycin
Drugs that lower carbamazepine levels
Theophylline, cisplatin
Carbamazepine can lower the levels of what drugs
OCP, warfarin
Time until lithium at steady state
5-8 days
Treatment hyperarousal PTSD
Clonidine, beta-blockers
Seizures during clozapine treatment are related to
Dose
Treatment of cataplexy
Antidepressant
Pt with hyperthermia, muscular rigidity, autonomic instability, AMS, increased CPK/LFT/leukocytes
NMS
Treatment of NMS
"1. Stop antipsych, 2. Treat EPS with antiparkinson meds, 3. If severe, dantrolene/bromocriptine/amantidine"
Imipramine uses
ADHD, nocturnal eneuresis
Lithium level to treat acute mania
1-1.5 mEq/L
Treatment lithium-induced tremor
"1. Reduce dose, 2. Stop caffeine, 3. Slow release lithium preparation, 4. Beta-blocker"
Eriksonian Stage birth-1year
basic trust v mistrust
Eriksonian Stage 1-3year
autonomy v shame
Eriksonian Stage 3-5year
initiative v guilt
Eriksonian Stage 5-13year
industry v inferiority
Eriksonian Stage 13-21year
identity v role confusion
Eriksonian Stage 21-40year
initimacy v isolation
Eriksonian Stage 40-60year
generativity v stagnation
Eriksonian Stage 60year-death
integrity v despair
Infant development phase 1st two months
autistic phase
Infant development phase 2-6month
symbiosis
Infant development phase 6-10month
differentiation
Infant development phase 10-16month
practicing
Infant development phase 16-24month
rapprochement
Infant development phase 3year
object constancy
Id
Instinctual drives
Ego
Balance id and superego
Superego
Internalized parental / society
Primary process thinking
Nonlogical, primitive, denies the existence of negatives (operational style of id, manifested in dreams)
Primitive/Narcissistic defense mechanisms
Denial, projection, distortion
Immature defense mechanisms
Acting out, introjection, passive aggressive, somatization
Neurotic defense mechanisms
Displacement, externalization, inhibition, reaction formation, repression, intellectualization, rationalization
Mature defense mechanisms
Sublimation, altruism, asceticism, anticipation, suppression, humor
3 psychological defense mechanisms in OCD
1. Undoing 2. Isolation 3. Reaction formation
Phases of separation in infant
Protest —> despair —> detachment
Freud psychosexual development first 18 months
Oral
Freud psychosexual development 18-36 months
Anal
Freud psychosexual development age 3
Phallic
Freud psychosexual development 3-5
Oedipal
Freud psychosexual development 5-11/13
Latency
Freud psychosexual development puberty-young adulthood
Genital
Primary metabolite of dopamine
Homovanillic acid
Temporal lobe epilepsy sx
Hyposexuality, emotional intensity, viscosity
EEG in REM sleep
Random, fast, sawtoothed, low-voltage waves
Mesial frontal lobe lesion
"slowing of motor function, speech, emotional reaction (at worst, mute and akinetic)"
Orbitofrontal lobe lesion
Abnormal social behvavior, good opinion of slef, jocularity, sexual disinhibition, lack of remorse or concern for others
Sumatriptan acts on
5HT-1D
Atypical antipsychotics act on what two receptors
"5HT-6, D4"
Circadian rhythms affect what receptor
5HT-7
Anxiolytics affect what serotonin receptor
5HT-1A
Typical antipsychotics act on what receptor
D2
Antiparkinson drugs act on
M4 (cholinergic)
Diphenhydramine acts on
H1
Central achromatopsia
Inability to perceive color
Simultanagnosia
Inability to integrate visual scene + perceive it as a whole
Gerstmann syndrome (4)
"Agraphia, Acalculia, R/L disorientation, Finger agnosia"
Gerstmann syndrome is a lesion of the
Dominant parietal lobe
Apperceptive visual agnosia
Inability to identify/draw items using visual cues
Oculomotor apraxia
Inability to direct gaze rapidly
Prosopagnosia
Inability to recognize faces
Color agnosia
Inability to recognize color (but able to match it)
Balint syndrome (3)
"Optic ataxia, Oculomotor apraxia, Simutanagnosia"
Balint syndrome is a lesion of the
bilateral parieto-occipital lobes
Anton syndrome
failure to acknowledge blindness
Anton syndrome is a lesion of the
bilateral occipital lobes
Associative visual agnosia
Inability to name/use objects, but able to draw them
Associative visual agnosia is a lesion of the
bilateral medical occipitotemporal lobes
What disorder causes decreased latency of REM sleep
MDD
Most common gene implicated in hereditary Alzheimer's
"Presenilin 1 (70-80%), Presenilin 2 (20-30%), APP (2-3%)"
Presenilin 1 is found on
Chromosome 14
Presenilin 2 is found on
Chromosome 1
APP is found on
Chromosome 21
Partial complex seizures originate in the
temporal lobe
aura of odor (brain region)
Uncus (area at tip of temporal lobe)
Night terrors occur during
Non-REM sleep
Increased BP, HR, erection, dreaming occur during
REM sleep
Serotonin metabolite
5-HIAA
OCD involves ____ pathways
Serotonin
What NT is most commonly associated with Alzheimer
ACh
Neuropeptide Y
Stimulates appetite
Huntington disease involves damage to what brain structure
Caudate nucleus
R prefrontal lesion
Laughter, euphoria, tendency to joke and make puns
L prefrontal lesion
Depression, uncontrollable crying
Dorsolateral frontal lesion
Decreased planning + motivation (pt is inattentive, echoes examiner's questions)
Amygdala lesion
Impaired ability to recognize fear/anger from external cues (voice, facial expression)
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