# Nucleotides Exam 2- James

Fill in the blanks: Pre-systemic biotransformation, also known as _______ biotransformation, can occur in the _______ and the ______ for orally administered drugs
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1. Drug w/ MW 285: would undergo entero-hepatic cycling because (285 +176 > 400)
Drug w/ MW 151: would not undergo entero-hepatic cycling because (151 + 176 < 400)
2. The glucuronide will be excreted in bile and enter the intestine where in the lower intestine B-glucuronidase will convert the drug-glucuronide to the parent drug, which is reabsorbed.
3. Prolong duration of action
The following reaction occurs at a very slow rate in some individual patients and a very rapid rate in other individuals, compared with the majority of people.
1. Explain why this is the case.
2. Name the enzyme that carries out the reaction.
3. Approximately what percentage of an average US population would carry out this reaction very slowly.