Drug w/ MW 151: would not undergo entero-hepatic cycling because (151 + 176 < 400)
2. The glucuronide will be excreted in bile and enter the intestine where in the lower intestine B-glucuronidase will convert the drug-glucuronide to the parent drug, which is reabsorbed.
3. Prolong duration of action
1. Explain why this is the case.
2. Name the enzyme that carries out the reaction.
3. Approximately what percentage of an average US population would carry out this reaction very slowly.
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K.B. is a 21-year-old man with a past medical history (PMH) of seizure disorder controlled with carbamazepine Tegretol). He was accidentally struck in the head by a pitched baseball while batting in a baseball game. He was unconscious for about 5 seconds, then awakened and was alert and responsive. After a few hours, K.B. returned home with complaints of a "splitting" headache, drowsiness, slight confusion, and some nausea. K.B. was taken to the local hospital emergency department (ED), where a computed tomography (CT) scan revealed a left subdural hematoma. He was been transferred to your medical center 70 miles away, which has a neurosurgeon on call, and is being admitted from the ED to the medical unit.
Describe five interventions that could assist in managing K.B.'s pain.