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NR 508 Pharmacology Final

Terms in this set (92)

Serentil/mesoridazine is a first generation antipsychotic

-Most common side effects of antipsychotics are parkinsonian syndrome, akathisia, dystonia, neuroleptic malignant syndrome, and TD.
-General body: Polydipsia, systemic lupus erythematous-like symptoms.
-Hypersensitivity: Pruritus, dry skin, seborrhea, erythema, uritcaria, maculopapular
hypersensitivity reactions, asthma, laryngeal edema, hair loss.
-Respiratory: increased depth of respiration. laryngospasm, bronchospasm, dyspnea, suppression of cough reflex.
-Cardiovascular: hypotension, hypertension, tachycardia, bradycardia, light-headedness, faintness, dizziness, cardiac arrest, syncope, quinidine-like effect (increased QT interval, ST depression, and changes in AV conduction).
-GI: Dyspepsia, increased appetite, increased weight, antiemetic.
-Hemic and lymphatic: agranulocytosis (rare), leukopenia, leukocytosis, anemia, thrombocytopenia, aplastic anemia, hemolytic anemia, pancytopenia
-Endocrine: lactation and breast engorgement in females, galactorrhea, mastalgia, amenorrhea, menstrual irregularities, changes in libido, hyperglycemia, hypoglycemia, glucosuria, raised cholesterol, SIADH, hyponatremia.
-CNS: headache, weakness, tremor, twitching, tension, jitteriness, fatigue, slurring, insomnia, vertigo, drowsiness.
-Autonomic: Dry mouth, nasal congestion, n/v, paresthesia, anorexia, pallor, perspiration, constipation, diarrhea, frequency or incontinence, polyuria, enuresis, priapism, ejaculation inhibition, male impotence.
-Hepatic: Liver dysfunction
-Behavioral effects: exacerbation of psychotic symptoms including hallucinations, catatonic-like states, lethargy, restlessness, hyperactivity, agitation, bizarre dreams, depression, paranoid reactions.