Increase in Glucagon = increase in Ca2+ spikes.
1) Ca2+ binds effector protein (Ca.Cam)
2) Response element activated (Ca.Cam Kinase II)
3) This phosphorylates substrate protein and activates then enzyme (Phosphorylase Kinases-P)
4) This then phosphorylates its substrate protein (Phosphorylase)
5) Which then breaks down glycogen to glucose and releases it into the blood.