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Immunohematology Test Chapters 5 and 6 Review
Terms in this set (55)
What ABI phenotype would agglutinate in the presence of anti-A,B produced by group I individuals?
ABO phenotype that contains the most H antigen and the least H antigen, respectively, on the red cell surface are
A recipient with group A phenotype requires a transfusion of 2 units of frozen plasma. Which types are appropriate to select for transfusion?
A and AB
A patient's red cells are agglutinated by anti-B, but not by anti-A. What is this patient's ABO phenotype?
What is the test procedure that combines patient's serum with commercial A1 and B reagent red cells?
ABO reverse grouping
What possible ABO phenotypes could be expected in the offspring of a group A man who marries a group AB woman. The father of the group A man was O
A, AB, B
According to Landsteiner's rule (law), what ABO antibody will be detected in a group A individual's serum?
What is the appropriate strategy if the results of red cell and serum testing in the ABO typing procedure have negative agglutination reaction?
Incubate at room temperature, use auto-control or at 4 degrees Celsius; Investigate history
What is the agglutination reaction of red cells from a Bombay phenotype when combined with anti-H lectin?
Given the following ABO phenotyping data
Anti-A: 2+mf A1 cells: 0
Anti-B: 0 B cells: 3+
Is there a discrepancy? If so, what could be a plausible explanation for the discrepancy?
Yes; Group O given to group A recipient
What forward typing reagent can be used to confirm group O units before placing them in inventory?
Which situation is most likely to cause intravascular hemolysis when an incompatible transfusion is given?
Group B packed cells given to group O recipient
What is the most likely cause of discrepancy when a blood sample from a 90-year olf man is submitted to the blood bank for a type and screen before surgery and the forward type demonstrates as a group A, whereas the revers type appears to be group AB
Which immunoglobulin class does most "naturally occuring" ABO system antibodies fall into
What substances are found in the saliva of a group a person who also inherited the secretor gene?
A and H antigen
What percentage of the group A population are type A2
Approximately with is the percentage of individuals who demonstrate H in their saliva?
To distinguish between an A1 and A2 blood type, which reagent is used?
Why is it sometimes necessary to distinguish A1 and A2 blood types?
To resolve discrepancies between forward and reverse typing
What subgroup of A possess the least amount of A antigen?
Immunodominant sugar: Group A
Immunodominant sugar: Group B
Immunodominant sugar: Group O
Immunodominant sugar: H antigen
Immunodominant sugar: Bombay
Which phenotype will react with anti-f?
Write the possible Fischer-Race genotypes for the below reactions
Anti-C > + Anti- c > +
Anti-D > + Anti- e > +
Anti-E > +
What does the weak D test detect?
a weak D-antigen
A donor who tested negative with anti-D reagent upon immediate-spin and positive in antihuman globulin test will be labeled as
A patient phenotypes as D+C+E-c-e+. Precit the most likely genotype
How is it genetically possible fr a child to phenotype as D-negative?
Both parents are heterozygous D-positive
Current theory regarding the genetics of the Rh system suggests that
Rh system antigens are coded by two closely linked genes
Red cells that phenotype as D-negative indicate
There is no genetic material inherited from the RHD gene from both parents
What is the interpretation when Anti-D reagent and the D control were tested with patient's red cells and both tests were 2+ agglutination reactions?
Unable to interpret without further testing
What can cause the D antigen expression to be weaker?
partial D expression and RH gene which is weak and inheriting the C antigen instead of the D antigen
What other Rh system antibody should be investigated if an anti-E is identified in a patient who recently received a transfusion?
What is the frequency of the D-negative phenotype in the population?
How is testing for the weak D expression performed?
IAT with anti-D
The numeric Rh4 nomenclature refers to which antigen in the Rosenfield notation?
On which red cells is the LW antigen expression typically stronger on?
D positive red
Why is the determination of the D antigen important for woman during pregnancy?
the mother should be given Rh immune globulin to prevent potential formation of anti-D during delivery of a D-positive infant
The inheritance of the Rh antigens are
What is the immunoglobulin class of most Rh system antibodies?
An individual's red cells gave the following reactions with antisera:
Anti-D: 4+ Anti-c
Anti-C: 3+ Anti-e
Anti-E: 0 Rh control
What is the most probable genotype?
If D-negative red cells are transfused to an R1R1 individual, what is the most likely Rh antibody that could develop?
What is the most likely explanation if a D-positive person appears to have anti-D in their serum?
Exposure to O-positive blood in transfusion or pregnancy
What is associated with the Rhnull phenotype?
membrane abnormalities immunized Rh null individuals may produce anti-Rh 29 and mutation of the Rh regulator gene
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