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Quiz 5 study set
Terms in this set (49)
Which of the following products is a molecular dispersion?
3. Colloidal dispersion
What will happen to the rate of sedimentation if the particle size is increased 10 times?
1. Increases 1000
2. Decreases 100 times
3. Decreases 10 times
4. Increases 10 times
5. Increases 100 times
The suspensions of a drug required of particles by glycerin. Before the addition of glycerin, different contact angles were observed by wetting experiments for different suspensions made from the same drug. Which of the following suspensions would require the most glycerin?
1. Suspended particles displayed a contact angle of 145*
2. Suspended particles displayed a contact angle of 105*
3. Suspended particles displayed a contact angle of 90*
4. Suspended particles displayed a contact angle of 15*
Vistaril Oral suspension contains ______________.
1. hydroxyzine pamoate
4. Penicillin V
Which of the following is a good viscosity modifier to prepare suspensions?
1. Sodium lauryl sulfate
3. Purified water
Which of the following methods/instruments is not used to prepare lyophobic colloids?
1. Colloid mills
3. Electric arc
4. Solvent changing
5. Ultrasonic generators
Lyophobic colloids are characterized by _____________.
1. Spontaneous emulsification
2. Stability with electrolytes
3. Unchanged viscosity
4. None of these
21CFR 321 for INDs is a _____________.
Which of the following types of emulsions is greasy?
1. Vanishing cream
Upon addition of a large quantity of water, an emulsion breaks. This is an oil-in-water emulsion.
In which of the following aspects a suspension is superior to solid dosage forms?
1. Chemical stability
2. Dose flexibility
3. Dose accuracy
5. Taste masking
Which of the following statements is consistent with defocculated suspensions?
1. Redispersion is easy
2. Particles form loose aggregates
3. Particles settle rapidly
4. Sediments may transform to hard cake
5. Ultimate sedimentation volume is large
Degree of flocculation is the ratio of sedimentation volume of the flocculated system to the sedimentation volume of the completely deflocculated system. Its unit is ______________.
Which of the following suspensions is used in anxiety?
A colloid mill is mostly used to prepare ____________.
1. Solution dosage forms
2. Lyophilic colloids
3. Lyophobic colloids
4. None of these products
Osmotic pressure is a type of___________ property of colloids.
The Law related to compounding practices is__________.
Standard applications for new drugs (NDAs) are required to be reviewed in ______________.
1. 6 months
2. 11 months
3. 2 years
4. 6-10 years
Which of the following statements regarding emulsions is incorrect?
1. They are homogeneous systems.
2. Emulsifying agents are used to stabilize pharmaceutical emulsions.
3. They are thermodynamically unstable
4. They have different types, e.g. o/w, o/w, o/w/o, w/o/w types.
5. Cold cream and vanishing cream are types of emulsions.
Which of the following tests is not used to identify the type of emulsions?
1. Fluorescence test
2. Conductivity test
3. Dilution test
4. Dye test
5. Adsorption test
When the particle charge in a suspension is high, they tend to form a deflocculated suspension. In such a case electrolytes of opposite charge are added to control the zeta potential and obtain flocculated suspensions.
Which of the following is a good emulsifying agent, but not a surfactant?
1. A solubilizing agent
2. An antifoaming agent
3. Sodium lauryl sulfate
Which of the following products displayed failures with repackaged products and is
not a good product to repack?
1. Amoxicillin suspension
2. Maalox® suspension
3. Phenytoin sodium suspension
4. Ferrlecit® dispersion
What is critical micelle concentration (CMC) in an association colloid?
1) The concentration of amphiphiles below which micelles start settling
2) The concentration of amphiphiles above which micelles start settling
3) The concentration of amphiphiles below which micelles start forming
4) The concentration of amphiphiles above which micelles start forming
5) The concentration of amphiphiles at which micelles start dissolving
When potential difference in a colloidal dispersion, the phenomenon is called ________.
3) sedimentation potential
4) streaming potential
Safety, pharmacokinetics, and toxicity of drugs in animals is required to obtain permission for _____ studies.
When a clinical study is conducted early in Phase I, it is most likely a/an _________.
1) treatment IND
2) parallel track IND
3) exploratory IND
4) subpart E
All of the following EXCEPT this one are advantages of emulsion dosage forms over solution dosage forms?
1) Enhanced bioavailability of lipophilic drugs
2) Increased efficacy of some oil drugs
3) Better stability of certain drugs
4) Dosing accuracy
5) Extending drug release
In which method first oil is mixed with the emulsifier to prepare the primary emulsion?
1) Dry gum method
2) Wet gum method
3) English method
4) Forbes bottle method
5) In situ soap method
Which of the following is an application to receive FDA approval of a new drug?
How would you define radio labeling?
1) producing radionuclide in a cyclotron
2)Treating toxicity occurred by radiopharmaceuticals
3)Incorporation of radioactive atoms into a target molecule 4)Purification of radioactive isotopes from mixture
5)Dilution of a solution containing radiotracer to a safe level
Particles in a disperse system are 0.1 nm in diameter, diffuse rapidly and can pass through regular filter paper. This dispersion is a ________________.
1) molecular dispersion
2) colloidal dispersion
5) coarse dispersion
For which of the following aspects suspension dosage form would have NO advantage over solution dosage form?
1) Reduction of dose volume
2) Stability against hydrolysis
3) Taste masking
4) Depot therapy
5) Dose uniformity
Which of the following can be deduced for sedimentation of suspension preparations?
1) Larger particles show slower sedimentation.
2) Sedimentation can be increased by using a more viscous medium.
3) Lighter particles would sediment faster.
4) An increase in temperature would create faster sedimentation.
5) A denser medium would decrease the rate of sedimentation
Which of the following methods/instruments is NOT used to prepare lyophobic colloids?
1) Colloid mills
2) Ultrasonic generators
3) Electric arc
5) Solvent changing
All of the electrical properties of colloidal systems have a common application and that is to determine the _________________ of the systems.
1) zeta potential
3) particle size
4) molecular weight
5) particle shape
The miscibility of an emulsion with water depends on the type of the emulsion. Identify the type of emulsion that is water washable?
4) Cold cream
In an emulsion, the phase in which the emulsifying agent is more soluble typically becomes the external phase. This can be best explained by ___________ theory of emulsification.
1) plastic or interfacial film theory
2) adsorption theory
3) electrical double layer theory
4) oriented-wedge theory
5) phase volume ratio theory
Which of the following statements is NOT true for rectal suppositories?
1) The pH of the rectal fluid is about neutral.
2) Drug absorption is fast and complete via rectal route due to its large surface area.
3) Diarrhea, tumor, and tissue dehydration may influence drug absorption.
4) Evacuant enema may increase drug absorption.
5) Blood and lymphatic vessels are present in the sub-mucosal region
You could not see the particles in a disperse system even by using an electron microscope. This disperse system must be a ________________.
1. molecular dispersion
2. coarse dispersion
3. colloidal dispersion
Which of the following statements is consistent with flocculated suspensions?
1. Redispersion is difficult.
2. Particles in sediments are weakly bonded.
3. Particles stay separate from one another.
4. Ultimate sedimentation volume is small.
5. Particles settle slowly.
Which of the following materials are generally used as flocculating agents?
1. Suspending agents
2. Finely divided solids
4. Wetting agents
The rate of particle settling in a suspension dosage form can be decreased by ____________.
1. a decrease in particle density
2. an increase in particle diameter
2. a decrease in medium density
3. a change in particle shape
4. a decrease in medium viscosity
Which of the following products displayed failures with repackaged products and is not a good product to repack?
1. Dilantin® suspension
2. Ferrlecit® suspension
3. Synthroid® suspension
4. Amoxil® suspension
5. Venofer® suspension
Which of the following is NOT true for lyophilic colloids?
1. Generally inorganic compounds form this type of colloids.
2. They form spontaneously.
3. Dispersed phase and dispersion medium have affinity for each other.
4. Solid particles are solvated by the medium.
5. They are relatively easy to prepare.
In which of the following methods/instruments of lyophobic colloids one of the solvents is evaporated to obtain colloidal particles?
1. Chemical reaction method
2. Ultrasonic treatment
3. Electric arc method
4. Colloid mills
5. Solvent change method
Venofer® colloid contains what type of iron compound?
1. Ferrous succinate
2. Iron sucrose
3. Ferric gluconate
4. Ferrous fumarate
5. Iron dextran
For which of the following products, bioequivalence studies are waived when the compositions of brand and generic products are qualitatively and quantitatively the same?
2. Lyophobic colloids
Safety, pharmacokinetics, and toxicity of drugs in animals is required to obtain permission for _____________.
1. IND studies
2. NDA studies
3. BE studies
4. BLA studies
5. ANDA studie
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