Terms in this set (33)
- Acute inf lammation progressing
-Persistent Infection by microbes
-Prolonged Exposure to toxic Agents
Infiltration with mononuclear cells(macrophages, lymphocytes & plasma cells)
Tissue destruction, done by
Inf lammatory cells
Macrophages which ingest the dead tissue & the causative agents
Repair involving the process of
In Bone marrow
In the Circulating Blood
Mechanisms Of Macrophage
1-from the circulation
Macrophages activated by
T lymphocytes activeted by
-migrate by CAM and chemokines
Strong chronic inf lammatory reactions
When tissues assume the features of lymph nodes with well-formed germinal centers.
Develop from B lymphocytes
Participate in both acute and chronic inf lammatory reactions
Binds the Fc portion of the IgE antibody
Mediated by IgE
Eotaxin - chemokine to prime eosinophils for chemotaxis
Chronic inf lammation may continue to show neutrophilic infiltrates, due to persistent microbes or necrotic cells
Non specific histological appearance.
Diffuse accumulation of lymphocytes, plasma cells and macrophages.
Specific (Chronic Granulomatous)
Focal response that leads to the formation of a specific lesion -
Granuloma. Examples: Tuberculosis, leprosy, syphilis.
collection of modified macrophages, called epithelioid cells
caseating granulomas in tuberculosis
there is a central mass of necrotic tissue
formed by fusion of macrophages and contain many nuclei (multi-nucleated giant cells).
1- Mycobacterium TB
2- Mycobacterium Leprae
3- "Treponema Pallidum"
Allergic conditions and parasite infestations
Certain infections (typhoid fever, some viruses, rickettsiae, and certain protozoa)
decreased number of circulating white cells (leukopenia)
Raised Erythrocyte Sedimentation Rate(ESR)
Fibrinogen binds to erythrocytes and causes them to form stacks (rouleaux formation) .
Exogenous pyrogens(bacterial lipopolysaccharides) stimulate
leukocyte release of Endogenous pyrogens (IL-1,TNF)-> stimulate synthesis of PGs by endothelial cells of hypothalamus which ->resets body temp
In severe bacterial infections high levels of TNF cause
2-disseminated intravascular coagulation (DIC)
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