How can ischemia affect a cell?
-decreased oxphos leads to decreased ATP
-dec. ATP leads to Na pump inaction, inc. glycolysis
-Na pump inaction leads to inc. cytosolic Na, inc. glycolysis leads to lactic acid buildup
-inc. cytosolic Na leads to swelling, activation of -ases; lactic acid buildup decreases cellular pH, inactivating proteins
-ribosomes detach, chromatin clumps up, cell membrane blebs